在韩国婴儿接种轮状病毒疫苗后,肠受孕风险在韩国婴儿中存在
Haerin Cho1, Na-Young Jeong2, Hee-Jin Kim1
1Department of Health Convergence, Ewha Womans University, Seoul, Republic of Korea.
Vaccine
|September 24, 2025
概括
使用Rotarix,但不使用RotaTeq的罗塔病毒疫苗接种与韩国婴儿在第一剂接种7天内内内接的风险更高有关. 这一发现凸显了Rotarix的潜在安全问题.
科学领域:
- 儿童传染病 儿童传染病
- 疫苗安全和疫苗监督工作
- 胃肠病学和肝病学 胃肠学和肝病学
背景情况:
- 经过罗塔病毒疫苗接种后的肠受孕风险是一个已知的问题,不同类型的疫苗报告了不同的关联.
- 之前的研究表明,Rotarix和RotaTeq疫苗之间的肠道受精风险可能存在差异.
研究的目的:
- 为了评估在接种Rotarix和RotaTeq疫苗后,韩国婴儿内受孕的风险.
- 为了比较与每种罗塔病毒疫苗类型相关的内发生率.
主要方法:
- 使用韩国国家卫生和疫苗注册数据,采用了自我控制的案例系列研究设计.
- 包括在2016年6月至2022年12月期间接受Rotarix或RotaTeq的1岁以下婴儿.
- 条件波桑回归分析了疫苗接种后在特定风险间隔内内肠异常的发病率比率 (aIRR).
主要成果:
- 在第一剂Rotarix (aIRR 3.15) 后1-7天内观察到统计学上显著增加的内受孕风险.
- 在所有评估的风险间隔中,没有检测到RotaTeq疫苗接种对肠道吸收风险的显著增加.
- 罗塔里克斯的可归因风险为每10万剂2.17个.
结论:
- 接种Rotarix的第一剂与在接种疫苗后7天内,婴儿内的风险增加有关.
- 接种RotaTeq疫苗并没有显示出与增加内肠受精风险的显著关联.
- 这些发现强调了针对疫苗的安全监测的重要性.
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