住宅绿化与冠心病之间的关联:蛋白质组学和miRNA微阵列分析
Le Yang1, Qinfei Wei1, Jianhui Guo2
1Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China.
International journal of hygiene and environmental health
|September 24, 2025
概括
生活在更绿色的地区可以降低冠心病 (CHD) 的风险. 表观遗传因素,特别是LTBP1和miR-379-5p,通过影响血管收缩和免疫炎症来调解这种保护作用.
科学领域:
- 环境流行病学环境流行病学
- 分子生物学分子生物学
- 心血管科学 心血管科学
背景情况:
- 绿色暴露与心血管疾病有关,但潜在的生物机制尚不清楚.
- 冠心病 (CHD) 是一个重要的公共卫生问题,需要对环境和分子决定因素进行调查.
- 表观遗传修饰,包括蛋白质和microRNA表达,是将环境因素与疾病联系起来的潜在途径.
研究的目的:
- 研究表观遗传机制,特别是蛋白质组和miRNA表达,将住宅绿色暴露与冠心病 (CHD) 联系起来.
- 确定特定的分子介质,包括蛋白质和微RNA,参与绿色和心脏病之间的关联.
- 探索心血管代谢风险因素在调解绿色和心血管疾病之间的关系中的作用.
主要方法:
- 一项对2387名参与者 (816人患有心脏病) 的人口研究使用正常化差异植被指数 (NDVI) 评估了住宅绿色.
- 一般化的添加模型和受限制的立方线分析了绿色和心脏病之间的关联,并对风险因素进行调解分析.
- 蛋白质组学和miRNA微阵列查确定了候选分子,随后使用Elisa和qRT-PCR对蛋白质 (LTBP1) 和miRNAs (miR-379-5p) 进行验证.
主要成果:
- 在1000米范围内更高的绿色暴露与心脏病风险降低有关 (OR:0.86).
- 系统性血压,淋巴细胞计数,单细胞计数和禁食血糖均为绿色与心脏病相关的媒介.
- 在心脏病患者中,LTBP1和miR-379-5p的表达差异很大,并且显著调节了绿色对心脏病的影响,miR-379-5p调节了更大的比例.
结论:
- 住宅绿色暴露与心脏病风险相反相关.
- 已确定LTBP1和miR-379-5p是绿色-心血管疾病途径中的关键分子调解剂,可能调节血管收缩和免疫炎症.
- 这些发现凸显了城市绿地对心血管健康的重要性,并为预防心血管疾病提出了新的表观遗传目标.
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