药物加载对通过无针电纳米纤维素/奇托桑/聚乳酸基药物递送系统持续释放的药物加载的影响
Murtaza Haider Syed1, Md Maksudur Rahman Khan2, Norhayati Abdullah1
1Faculty of Chemical and Process Engineering Technology, Universiti Malaysia Pahang Al-Sultan Abdullah, Gambang, Pahang, Malaysia.
International journal of biological macromolecules
|September 24, 2025
概括
无需电 (NES) 创建了用纳米晶纤维素 (NCC) 载体的奇托/聚乳酸纳米纤维,以改善药物输送. 在NCC载体上预装载药物导致了优异的三步持续释放,增强了药物输送系统.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 药物输送系统 药物输送系统
背景情况:
- 传统的基于针的电 (ES) 面临着诸如针塞和低吞吐量等挑战.
- 无需电 (NES) 为纳米纤维制造提供了一个先进的替代方案.
- 纳米纤维由于其高表面与体积的比率,对药物输送具有前景,但目前的系统在持续释放时间和生物相容性方面扎.
研究的目的:
- 使用NES制造奇托/聚乳酸纳米纤维,用于药物输送应用.
- 调查纳米纤维素 (NCC) 比率作为药物载体对纳米纤维特性和药物释放的影响.
- 评估不同的药物加载方法,以优化持续的药物输送.
主要方法:
- 通过不必要的电回旋 (NES) 制造桑/聚乳酸 (10:0.1 w/v%) 纳米纤维.
- 纳入不同比例 (0.025,0.05,0.1 w/v%) 的纳米晶纤维素 (NCC) 作为药物载体.
- 使用扫描电子显微镜 (SEM),富里埃变换红外光谱 (FTIR),X射线衍射 (XRD) 和热重力测量分析 (TGA) 的表征.
主要成果:
- 增加NCC含量提高了热稳定性和药物矩阵兼容性.
- 较高的NCC百分比导致水友性增加和药物输送系统 (DDS) 的更快解体.
- 用药物预装到NCC载体上的DDS表现出最佳的三步持续释放配置.
结论:
- 对于制造用于药物输送的奇托/聚乳酸纳米纤维,NES是有效的.
- 作为一个可行的载体,NCC会影响DDS特性和药物释放动力学.
- 在NCC纳米载体上预装药物提供了一个有希望的战略,可以在不影响生物降解的情况下持续输送药物.
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