相关实验视频
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Generation of Alginate Microspheres for Biomedical Applications
Published on: August 12, 2012
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双酸盐交叉链接的酸盐-高林水凝珠用于甲化加载:制备,表征,加载机制,体外释放研究和抗菌活性评估
Wei Liu1, Fizir Meriem2, Touil Sami3
1Zhejiang Pharmaceutical University, Ningbo, 315500, Zhejiang, China.
International journal of biological macromolecules
|September 24, 2025
概括
双阴离子交联的酸盐-高水凝珠 (Fe/Ca-Alg@K) 显示出药物输送的高效率,为治疗应用提供持续释放和强大的抗菌活性.
科学领域:
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
- 药物输送系统 药物输送系统
背景情况:
- 基于酸盐的水凝被广泛用于药物输送.
- 加入考林可以增强水凝的特性.
- 双离子交叉链接提供了改善的矩阵稳定性.
研究的目的:
- 评估作为药物输送系统的双阴离子交联酸-高水凝珠 (Fe/Ca-Alg@K).
- 调查CTC的药物加载和持续释放机制.
- 评估开发的水凝珠的抗菌功效.
主要方法:
- 使用SEM,EDS,FTIR,BET,TGA和XPS合成和描述Fe/Ca-Alg@K水凝珠.
- 药物封装效率和装载能力的确定.
- 在不同的pH值下进行体外药物释放研究.
- 抗菌测定以确认生物活性.
主要成果:
- Fe/Ca-Alg@K 水凝珠表现出多孔结构,稳定的结构和增强的热稳定性.
- 对于CTC,实现了高封装效率 (89.47%) 和负载能力 (317.03 mg/g).
- 观察到CTC的持续释放,释放动力学取决于pH值 (pH值1.2的准Fickian扩散,pH值7.4的扩散/膨胀/侵蚀).
- 释放的CTC显示出显著的抗菌活性.
结论:
- Fe/Ca-Alg@K 水凝珠对于控制CTC药物输送是有效的.
- 复合系统显示出局部抗菌疗法的潜力.
- 双离子交叉连接和高合并提高了药物输送应用中的水凝性能.
相关概念视频
02:54Ions as Acids and Bases
Salts with Acidic Ions
Salts are ionic compounds composed of cations and anions, either of which may be capable of undergoing an acid or base ionization reaction with water. Aqueous salt solutions, therefore, may be acidic, basic, or neutral, depending on the relative acid-base strengths of the salt’s constituent ions. For example, dissolving the ammonium chloride in water results in its dissociation, as described by the equation:
Salts are ionic compounds composed of cations and anions, either of which may be capable of undergoing an acid or base ionization reaction with water. Aqueous salt solutions, therefore, may be acidic, basic, or neutral, depending on the relative acid-base strengths of the salt’s constituent ions. For example, dissolving the ammonium chloride in water results in its dissociation, as described by the equation:
01:01Acid Halides to Carboxylic Acids: Hydrolysis
Hydrolysis of acid halides is a nucleophilic acyl substitution reaction in which acid halides react with water to give carboxylic acids. The reaction occurs readily and does not require acid or a base catalyst.
As shown below, the mechanism involves a nucleophilic attack by water at the carbonyl carbon to form a tetrahedral intermediate. This is followed by the reformation of the carbon–oxygen π bond along with the departure of a halide ion. A final proton transfer step yields carboxylic acid...
As shown below, the mechanism involves a nucleophilic attack by water at the carbonyl carbon to form a tetrahedral intermediate. This is followed by the reformation of the carbon–oxygen π bond along with the departure of a halide ion. A final proton transfer step yields carboxylic acid...
01:07Acid Halides to Amides: Aminolysis
Aminolysis is a nucleophilic acyl substitution reaction, where ammonia or amines act as nucleophiles to give the substitution product. Acid halides react with ammonia, primary amines, and secondary amines to yield primary, secondary, and tertiary amides, respectively.
In the first step of the aminolysis mechanism, the amine attacks the carbonyl carbon of the acyl chloride to form a tetrahedral intermediate. In the second step, the carbonyl group is re-formed with the elimination of a chloride...
In the first step of the aminolysis mechanism, the amine attacks the carbonyl carbon of the acyl chloride to form a tetrahedral intermediate. In the second step, the carbonyl group is re-formed with the elimination of a chloride...
01:14Acid Halides to Ketones: Gilman Reagent
Lithium dialkyl cuprate, also known as Gilman reagents, selectively reduces acid halides to ketones. The acid chloride is treated with Gilman reagent at −78 °C in the presence of ether solution to produce a ketone in good yield.
As shown below, the mechanism proceeds in two steps. First, one of the alkyl groups of the reagent acts as a nucleophile and attacks the acyl carbon of the acid chloride to form a tetrahedral intermediate. This is followed by the reformation of the carbon–oxygen double...
As shown below, the mechanism proceeds in two steps. First, one of the alkyl groups of the reagent acts as a nucleophile and attacks the acyl carbon of the acid chloride to form a tetrahedral intermediate. This is followed by the reformation of the carbon–oxygen double...
01:26EDTA: Auxiliary Complexing Reagents
EDTA titrations are usually carried out in highly basic conditions, where the fully deprotonated form of EDTA, Y4−, actively complexes with the free metal ions in the solution. Several metal ions precipitate as hydrous oxide (hydroxides, oxides, or oxyhydroxides) under these conditions, lowering the concentration of free metal ions in the solution. For this reason, auxiliary complexing agents or ligands such as ammonia, tartrate, citrate, or triethanolamine are used in EDTA titrations to...
01:17Ion Exchange
Ion exchange chromatography separates charged molecules from a solution by reversibly exchanging them with mobile, or 'active', ions associated with the oppositely charged stationary phase. This method can be used to separate ions, soften and deionize water, and purify solutions. The polymers comprising the ion-exchange column are high-molecular-weight and chemically stable polymers, crosslinked to be porous and essentially insoluble. They are also functionalized with either acidic or basic...