高光可持续的SnWO纳米颗粒作为计算机断层扫描 (CT) 的对比剂
Sk Najrul Islam1, Mudasir Ashraf Shah2, Mukesh Kumar3
1Interdisciplinary Nanotechnology Centre (INC), Z. H. College of Engineering and Technology, Aligarh Muslim University, AMU, Aligarh, UP-202002, India.
Nanomedicine : nanotechnology, biology, and medicine
|September 24, 2025
概括
锡酸纳米颗粒 (SnWO4 NPs) 在X射线计算机断层扫描 (CT) 成像中为对比剂提供了更安全的替代品. 这些纳米颗粒在临床前评估中表现出有效的对比性能,毒性最小.
科学领域:
- 材料科学 材料科学 材料科学
- 生物医学成像技术 生物医学成像技术
- 纳米技术 纳米技术
背景情况:
- 射线计算机断层扫描 (CT) 经常使用基于的对比剂.
- 对比剂可以引起敏感个体的不良反应.
- 需要更安全的替代方案来增强医学成像.
研究的目的:
- 生物合成和表征锡酸纳米粒子 (SnWO4 NPs) 作为潜在的CT对比剂.
- 为了比较SnWO4 NPs与商业基剂的CT对比效果.
- 评估SnWO4 NPs的体外细胞毒性和体内生物分布.
主要方法:
- 40nm SnWO4 NPs的生物合成和表征.
- 使用SnWO4 NP和OMNIPAQUETM Iohexol在80kVp的不同度 (1-10毫克/毫升) 中进行CT成像分析.
- 在体外细胞毒性测定HEK-293细胞,细胞和胸细胞.
- 在Wistar大鼠的体内生物分布研究.
主要成果:
- SnWO4NP显示出显著的CT对比度增强,尽管在同等度下低于.
- 在10毫克/毫升时,SnWO4NP的CT数为1477±40,而的CT数为2106±101.
- 对于SnWO4 NPs,观察到最小的体外细胞毒性和有利的生物分布.
- 在1mg/ml时,SnWO4NP的CT数为45±13,的CT数为63±10.
结论:
- SnWO4 NPs显示出作为CT成像中的有效和潜在的安全对比剂的承诺.
- 在初步研究中,纳米颗粒显示出良好的对比性能和低毒性.
- 需要进一步的研究,以探索它们在生物医学应用中的全部潜力.
相关概念视频
Computed Tomography
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
Positron Emission Tomography
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Radiological Investigation I: X-ray and CT
Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and the...


