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集群随机多层次干预的设计,以减少少数癌症患者转诊和癌症临床试验的招生障碍:ACT WONDERS研究

Dana E Rollison¹, Melany A Garcia², Rossybelle P Amorrortu³

¹Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA; Office of Health Data Services, Moffitt Cancer Center, Tampa, FL, USA.

Contemporary clinical trials

|September 24, 2025

概括

ACT WONDER2S是一个多层次的干预,旨在减少癌症临床试验 (CCT) 中黑人/非裔美国人和西班牙裔患者的障碍. 基线数据显示干预和对照组之间没有显著差异,为有效性测试铺平了道路.

科学领域:

在瘤学瘤学.
临床试验临床试验
健康差异在健康上的差异

背景情况:

非西班牙裔 (NH) 黑人/非洲裔美国人 (AA) 和西班牙裔癌症患者面临着癌症临床试验 (CCT) 参与的重大障碍.
这些代表性不足导致癌症护理和结果的健康差异.
解决这些系统性问题的多层次干预是必不可少的.

研究的目的:

介绍ACT WONDER2S多层次干预 (MLI) 的研究设计和基线特征.
降低NH黑人/AA和西班牙裔患者转诊和注册CCT的障碍.
建立一个评估干预措施在减少差距方面的有效性基础.

主要方法:

ACT WONDER2S MLI包括社区外展和数字干预.
地理空间分析确定了"优先区域",高NH黑人/AA和西班牙裔人口用于有针对性的干预.
优先区域被匹配并随机分为干预 (n=7) 或控制 (n=7) 组,使用从美国人口普查和公共来源收集的基线数据.

主要成果:

干预优先区域包括大约16.5%的NH黑人/AA和35.8%的西班牙裔人口.
干预和对照组在总人口规模,种族/种族比例或离癌症中心的距离方面没有观察到统计学上显著的差异.
基线癌症病例估计和CCT入学率在两组之间是可比的.

结论:

ACT WONDER2S有可能增加代表性不足的少数癌症患者在CCT中的转诊和招生.
成功实施可以作为减少全国CCT差异的典范.
需要进一步评估以确认干预措施的有效性.

关键词:

癌症临床试验癌症临床试验地理空间分析是什么?在健康方面存在差异.多层次干预措施多层次干预研究设计研究设计.

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