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7,8-二氧黄通过p53/Nrf2通路减弱了西斯普拉丁诱导的心肌细胞亡和线粒体功能障碍

Zhen Tian1, Ting-Ting Tan1, Yu-Wei Hu1

  • 1Department of Pharmacy, Northern Jiangsu People's Hospital, Yangzhou 225001, China; Yangzhou Key Laboratory of Clinical Pharmacy and Drug Research, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou 225001, China; College of Pharmacy, Dalian Medical University, Dalian 116044, China.

Toxicology and applied pharmacology
|September 24, 2025
PubMed
概括

7,8-二基黄 (7,8-DHF) 通过减少细胞死亡和炎症,保护心脏细胞免受化疗药物西斯普拉丁 (CDDP) 的影响. 这种化合物保持了线粒体的功能,并激活了抗氧化路径,为减轻心脏损伤提供了潜在的潜力.

关键词:
7,8-二氧化二氧化黄 7,8-二氧化二氧化黄心脏有毒性 - 心脏有毒性西斯普拉丁 (Cisplatin) 是一种线粒体中的线粒体.Nrf2 没有任何问题.在 p53 里,p53 是一个 p53 号码.

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