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使用第二波光散射进行水溶性药物溶解,超和聚合行为的高通量分析

Jitka Kalasová¹, Orly Tarun², Yevhen Shynkarenko³

¹University of Basel, Department of Pharmaceutical Sciences, Klingelbergstrasse 50, 4052 Basel, Switzerland; University of Applied Sciences and Arts Northwest. Switzerland, School of Life Sciences, Institute for Pharma Technology and Biotechnology, Hofackerstr. 30, 4132 Muttenz, Switzerland.

International journal of pharmaceutics

|September 24, 2025

概括

一种新的非共振第二波散射 (SHS) 方法准确地测量了药物的溶性和超和倾向. 这种技术为传统测试提供了快速,低消耗的替代方案,揭示了药物的自我组装行为.

科学领域:

分析化学分析化学
物理化学物理化学
制药科学制药科学

背景情况:

水溶性对于药物吸收和生物可用性至关重要.
现有的可溶性测定在准确性,速度和资源使用方面存在局限性.
开发新的,高效的可溶性评估方法是必不可少的.

研究的目的:

引入和验证一种使用非共振第二波散射 (SHS) 的新药溶解性评估方法.
为了将SHS衍生的溶解度数据与传统的高性能液态染色学 (HPLC) 测量进行比较.
使用SHS平台调查药物超和倾向和自我组装行为.

主要方法:

使用非共振第二波散射 (SHS) 检测水分子界面波动.
通过SHS测量了14种水溶性较差的药物的表面溶解度,并与HPLC数据进行了比较.
使用SHS评估了超和和自我组装行为 (化).

主要成果:

在SHS和HPLC可溶性数据之间观察到强烈的相关性 (r=0.9273).
凯托可纳和他莫西芬显示出优异的超和性能,与它们的热性能有关.
在SHS检测到5种超出溶解极限的模拟药物的状自我组装.

结论:

非共振SHS是一种有前途的分析工具,用于药物溶解度的确定.
该SHS方法提供了一个多功能,高吞吐量格式,最小的消耗.
SHS为药物聚合和自我组装提供了分子层面的见解.

关键词:

微粒度的临界度药物聚合药物聚合药物聚合高通量分析的分析.水溶性较差的药物在水溶性较差的药物第二个波散射的第二个波散射.自动组装自动组装可溶性选检查可溶性选检查可溶性选检查

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