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Updated: Jan 17, 2026

Functional Characterization of RING-Type E3 Ubiquitin Ligases In Vitro and In Planta
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在MARCHF6 E3无素酶中识别Ac/N-degron识别域的识别

Jihye Yang1, Cheol-Sang Hwang1

  • 1Department of Life Sciences, Korea University, Seoul, Republic of Korea.

Methods in enzymology
|September 24, 2025
PubMed
概括

研究人员确定了MARCHF6如何识别N端乙化 (Nt-乙化) 信号,这对于蛋白质降解至关重要. 这一发现澄清了Ac/N-degron路径,并为涉及蛋白质稳定性的疾病提供了治疗点.

关键词:
在Ac/N-degron下降.在Ac/N-域内.细胞内膜网膜的内细胞网膜.铁化是铁化的一种.在MARCHF6的6月份.通过Nα终端的乙化.跨膜蛋白质是一种跨膜蛋白质.

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