相关实验视频

Updated: Jan 17, 2026

Characterization of Neuronal Lysosome Interactome with Proximity Labeling Proteomics

Characterization of Neuronal Lysosome Interactome with Proximity Labeling Proteomics

Published on: June 23, 2022

cGAS-STING通路与溶酶体的相互作用

Yinfeng Xu¹, Wei Wan²

¹Laboratory of Basic Biology, Hunan First Normal University, Changsha, China.

Trends in biochemical sciences

|September 24, 2025

概括

循环GMP-AMP合成酶 (cGAS) -STING通路检测DNA并触发免疫力. 这一途径与溶酶体功能相互作用并调节,影响先天免疫反应.

科学领域:

免疫学免疫学免疫学
细胞生物学细胞生物学
分子生物学分子生物学

背景情况:

循环GMP-AMP合成酶 (cGAS) 刺激干扰素基因 (STING) 途径是天生的免疫系统的关键组成部分.
这一途径识别了细胞质DNA,启动了免疫级联.
新出现的证据表明,cGAS-STING信号传递和溶酶体活动之间存在联系.

研究的目的:

审查和讨论cGAS-STING通路和溶酶体功能之间的复杂关系.
要突出cGAS-STING信号是如何被 lysosomes 调节和影响的.
提供关于溶酶体在先天免疫中的双重作用的见解.

主要方法:

对最近关于cGAS-STING信号传递和溶酶体生物学研究的文献综述.
对将cGAS-STING激活与 lysosomal动态联系起来的实验数据的分析.
综合当前关于这两个细胞组成部分之间的相互作用的知识.

主要成果:

cGAS-STING信号不仅在溶酶体结束,而且还积极调节溶酶体功能.
溶解体在调节cGAS-STING反应的持续时间和强度方面发挥着重要作用.
这种相互作用影响着整体的先天性免疫激活和细胞平衡.

结论:

溶酶体是cGAS-STING天生的免疫通路中的关键调节器和效应器.
了解这种交叉通话对于破译天生的免疫力和开发治疗策略至关重要.
对这种相互作用的进一步研究可能会揭示免疫调节的新目标.

关键词:

这是ESCRT的特色.刺痛是一种刺痛.美国联邦税务法 (TFEB)cGAS 是一个气体.这是先天免疫力.lysosome 溶解酶体是如何形成的

更多相关视频

Site Specific Lysine Acetylation of Histones for Nucleosome Reconstitution using Genetic Code Expansion in Escherichia coli

Site Specific Lysine Acetylation of Histones for Nucleosome Reconstitution using Genetic Code Expansion in Escherichia coli

Published on: December 26, 2020

Evaluation of LC3-II Release via Extracellular Vesicles in Relation to the Accumulation of Intracellular LC3-positive Vesicles

Evaluation of LC3-II Release via Extracellular Vesicles in Relation to the Accumulation of Intracellular LC3-positive Vesicles

Published on: October 18, 2024

相关概念视频

Delivery Pathways to the Lysosome

Delivery Pathways to the Lysosome

Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...

Autophagy

Autophagy

Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...

Transport Across the Golgi

Transport Across the Golgi

While it is unclear how molecules move between adjacent Golgi cisternae, it is apparent that the molecules move from cis- cisterna, the entry face, to the trans- cisterna, the exit face. Experiments initially suggested vesicles that bud from one cisterna and fuse with the next cisterna to transport proteins between the cisternae. This vesicular transport model describes the Golgi apparatus as a relatively static structure with a unique enzyme composition in each cisterna. Molecules are...

Export of Misfolded Proteins out of the ER

Export of Misfolded Proteins out of the ER

After folding, the ER assesses the quality of secretory and membrane proteins. The correctly folded proteins are cleared by the calnexin cycle for transport to their final destination, while misfolded proteins are held back in the ER lumen. The ER chaperones attempt to unfold and refold the misfolded proteins but sometimes fail to achieve the correct native conformation. Such terminally misfolded proteins are then exported to the cytosol by ER-associated degradation or ERAD pathway for...

Lysosomes

Lysosomes

Lysosomes are membrane-enclosed spherical sacs derived from the Golgi apparatus. The most important function of the lysosome is degrading macromolecules and biological polymers that are released during membrane trafficking events such as the secretory, endocytic, autophagic, and phagocytic pathways. The degradation is carried out by several hydrolytic enzymes active in an acidic environment of the lysosomal lumen. These acid hydrolases are involved in cellular processes such as cell signaling,...

Lysosomal Hydrolases

Lysosomal Hydrolases

Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...