台湾消除肝脏疾病的国家战略
Chien-Jen Chen1, Chao-Chun Wu2, Shi-Lun Wei2
1Genomics Research Center, Academia Sinica, Taipei, Taiwan.
Journal of the Formosan Medical Association = Taiwan yi zhi
|September 24, 2025
概括
台湾 台湾 台湾 台湾
科学领域:
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 慢性肝病 (CLD),包括肝硬化和肝细胞癌 (HCC),是台湾的主要死亡原因.
- 慢性乙型肝炎病毒 (HBV) 和乙型肝炎病毒 (HCV) 感染是台湾末期肝病的主要驱动因素.
- 长期队列研究 (GECC和REVEAL) 提供有关肝病趋势的数据.
研究的目的:
- 评估台湾对CLD和HCC的公共卫生干预措施的有效性.
- 评估HBV免疫计划和抗病毒治疗计划的影响.
- 预计实现世界卫生组织 (WHO) 的HCV消除目标.
主要方法:
- 肝病死亡率数据的年龄周期队列分析.
- 全国HBV免疫计划的评估 (始于1984年).
- 慢性病毒性肝炎治疗计划 (2003年开始) 和HCV消除计划 (2017年开始) 的评估.
主要成果:
- 在免疫群中,HBV免疫显著降低了82%的CLD死亡率和63%的HCC死亡率.
- 在2004年至2018年期间,抗病毒治疗计划导致了CLD (26%) 和HCC (50%) 死亡率的显著降低.
- 台湾正在实现到2025年通过全国范围的查和护理级联管理实现世卫组织的HCV消除目标.
结论:
- 在台湾,HBV免疫计划在降低肝病死亡率方面表现出很高的有效性.
- 抗病毒治疗和HCV消除计划正在显著减少CLD和HCC死亡率.
- 预计台湾的综合战略将在2025年之前实现世卫组织的HCV消除目标.
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