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兰特斯对大鼠 Carotid 动脉血管收缩和放松反应的影响

Takayuki Matsumoto¹, Takayuki Nagano², Naoko Tanaka-Totoribe²

¹Second Department of Pharmacology, School of Pharmaceutical Sciences, Kyushu University of Medical Science, Nobeoka, Miyazaki 882-8508, Japan.

Biological & pharmaceutical bulletin

|September 24, 2025

概括

调节后激活正常的T细胞表达和分泌 (RANTES) 损害了大鼠动脉中乙胆诱导的放松. 这种效应与氧化生物可用性降低和活性氧物种增加有关.

科学领域:

心血管生理学心血管生理学
免疫学免疫学免疫学
血管生物学血管生物学

背景情况:

调节后激活正常的T细胞表达和分泌 (RANTES) 是一种具有多种细胞功能的化学因子.
兰特斯对血管反应性的影响尚不清楚.

研究的目的:

为了研究长时间暴露于RANTES对隔离的老鼠动脉血管反应的直接影响.

主要方法:

孤立的老鼠动脉被暴露在RANTES (100 ng/mL约24小时).
评估了对各种血管活性剂的收缩反应和对乙胆的放松反应.
氧化合成酶,环氧化原酶,活性氧物种和CCR5的作用使用特定的抑制剂和清除剂进行了评估.

主要成果:

暴露于RANTES并没有改变对血清素,高K+,上腺素,U46619或内甲素-1的收缩反应.
乙胆诱导的放松受到RANTES的影响,而对酸,cromakalim和NS19504的放松不受影响.
抑制氧化合成酶或环氧化原酶取消了RANTES诱导的乙胆放松受损.
抗氧化剂治疗和CCR5抗作用在RANTES治疗的动脉中部分恢复了乙胆诱导的放松.

结论:

兰特斯 (RANTES) 损害了大鼠动脉中乙胆诱导的放松作用.
这种损伤主要是由于氧化生物可用性降低而引起的,并且可能因活性氧物种增加和未掩盖的血管约束性前列腺素而加剧.

关键词:

動脈動脈 - 頸動脈動脈收缩的收缩收缩的收缩调节后激活正常T细胞的表达和分泌.放松放松放松

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