在患有高血压的患者中,TMAO水平与血管功能之间的关系
Takayuki Yamaji1,2, Yuji Takaeko2,3, Farina Mohamad Yusoff2
1Center for Radiation Disaster Medical Science, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
高血压患者的三甲基胺-N-氧化物 (TMAO) 水平与年龄,功能和药物使用有关. 然而,TMAO在这个研究小组中没有独立预测血管功能.
科学领域:
- 心血管医学 心血管医学
- 代谢学 代谢学 代谢学
- 高血压研究 高血压研究
背景情况:
- 升高的三甲基胺-N-氧化物 (TMAO) 是一种已知的高血压风险因素,与血管功能障碍相关.
- 内皮功能障碍与TMAO水平的增加有关.
- 高血压患者TMAO与血管功能之间的特定关系尚不清楚.
研究的目的:
- 在高血压患者中确定循环TMAO水平的独立预测因子.
- 调查TMAO水平与血管功能之间的关联,通过流媒体血管扩张 (FMD) 和甘诱导的血管扩张 (NID) 进行评估.
主要方法:
- 一项涉及333名高血压患者的横截面研究.
- 分析日志TMAO水平与临床参数之间的相关性,包括年龄,脂质,肌素,EGFR和尿酸.
- 多重线性回归以确定TMAO的独立预测因子;评估TMAO与口病和NID的关系.
主要成果:
- 记录TMAO水平与年龄,LDL胆固醇,肌素,eGFR和尿酸有显著的相关性.
- 记录TMAO水平的独立预测因素是年龄,eGFR和使用三种或更多的抗高血压药物.
- 虽然TMAO水平与口病和NID相关,但TMAO在调整混因子后并不是血管功能的独立预测指标.
结论:
- 高血压患者的循环TMAO水平与年龄,估计的淋巴膜过率 (eGFR) 和多药性 (≥3种抗高血压药物) 独立相关.
- 在这种高血压队列中,TMAO水平与血管功能 (FMD和NID) 并没有独立相关.
- 需要进一步的研究来阐明TMAO,高血压和血管健康之间的复杂相互作用.
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