怀孕前,怀孕期间和怀孕后的母亲精神疾病:瑞典的一项全国性队列研究
Emma Bränn1,2, Jerry Guintivano3, Yihui Yang4
1Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. emma.brann@ki.se.
Molecular psychiatry
|September 24, 2025
概括
母亲精神疾病的发病率随着时间的推移而增加,怀孕前诊断的显著增加. 虽然在怀孕期间风险下降,但在产后风险会反弹,特别是在抑郁症和精神病方面.
科学领域:
- 生殖精神病学是一种精神病学.
- 公共卫生流行病学 流行病学
- 心理健康研究 心理健康研究
背景情况:
- 孕产妇的心理健康是一个关键的公共卫生问题.
- 关于围产期内精神疾病的时间趋势和风险的证据有限.
- 了解这些趋势对于及时干预和支持至关重要.
研究的目的:
- 分析母亲精神疾病的日历时间趋势.
- 为了比较这些疾病的发病率比率 (IRR) 在怀孕前,怀孕期间和怀孕后.
- 为了确定不同精神疾病亚型的具体趋势.
主要方法:
- 在瑞典 (2003-2019) 进行的一项全国性队列研究包括来自1,052,977名妇女的1,799,010例怀孕.
- 事件精神病诊断是在怀孕前一年,怀孕期间和分娩后一年中确定的.
- 计算了根据年龄和日历年标准化的发病率 (SIR) 和IRR.
主要成果:
- 从2003年到2019年,母亲精神疾病的整体SIR增加了,怀孕前疾病的显著增加.
- 周SIR在怀孕前是稳定的 (~25/1000人年),在怀孕期间下降 (~4/1000),并在分娩后恢复到怀孕前的水平.
- 分别在分娩后5-15周和0-20周观察到抑郁症和精神病的具体增加.
结论:
- 随着时间的推移,母亲精神疾病的发病率有所增加.
- 虽然与之前相比,在怀孕期间和之后的整体风险较低,但在分娩后不久,抑郁症和精神病的风险增加.
- 这些发现强调了需要持续监测和有针对性的产后心理健康支持.
更多相关视频
08:45Kinematic Analysis Using 3D Motion Capture of Drinking Task in People With and Without Upper-extremity Impairments
Published on: March 28, 2018
11.3K
08:07Author Spotlight: Advancing Antiviral Strategies Through Novel Immunocapture and Mass Spectrometry Techniques
Published on: January 12, 2024
1.2K
相关概念视频
Disorders of the Female Reproductive System
4.5K
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
4.5K
Stress and Mental Health
1.7K
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
1.7K
Bipolar Disorder
1.4K
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
1.4K
Psychological and Sociocultural Causes of Schizophrenia
977
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
977
Development of the Oral Microbiota
65
The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
65
