坚持二次骨折预防与随后骨折的风险降低有关
Åshild Bjørnerem1,2,3, Jashar Khoshkhabari4, Ann Kristin Hansen4,5
1Department of Clinical Medicine, UiT - The Arctic University of Norway, N-9037, Tromsø, Norway. ashild.bjornerem@uit.no.
概括
参加骨折联络服务 (FLS) 在50岁以上的患者中显著降低了随后的骨折和死亡率. 坚持使用抗骨质疏松药物 (AOD) 进一步降低骨折风险,突出显示FLS和药物遵守对于预防二次骨折的重要性.
科学领域:
- 骨科和骨健康 骨科和骨健康
- 老年医学 老年医学
- 公共卫生 公共卫生
背景情况:
- 在全球范围内,二次骨折预防率非常低.
- 建议使用骨折联络服务 (FLS) 来解决骨质疏松症管理中的治疗缺口.
- 这项研究评估了挪威FLS和抗骨质疏松药物 (AOD) 的有效性.
研究的目的:
- 评估FLS对骨折率和死亡率的影响.
- 为了比较FLS患者与非FLS患者之间的结果.
- 评估AOD坚持对骨折风险和死亡率的影响.
主要方法:
- 挪威捕捉断裂倡议的一个单一中心子研究.
- 包括1936名年龄在50岁以上的男性和女性,有指数骨折 (2015-2018).
- 在12个月后,对FLS参与者 (n=1041) 与非参与者 (n=895) 和AOD参与者 (n=427) 与非参与者 (n=174) 患者的结果进行比较.
主要成果:
- 在平均3.5年的随访期间,FLS护理人员的随后骨折风险降低了20% (HR 0.80),死亡率降低了33% (HR 0.67),而非护理人员的死亡率则降低了33%.
- 与不坚持AOD的患者相比,坚持AOD的患者的后续骨折风险 (HR0.51) 降低了49%.
- 在AOD附属和非附属组之间没有观察到死亡率的显著差异.
结论:
- 接受FLS治疗的患者表现出明显降低后续骨折和死亡风险.
- 坚持服用抗骨质疏松症药物对于降低后续骨折风险至关重要.
- 这些发现强调了FLS和药物坚持在二次骨折预防策略中的重要作用.
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