传统的撒丁岛发酵牛奶的消费促进了老鼠肠道微生物群的组成和功能变化
Marcello Abbondio1, Antonio Palomba2, Monica Serra3
1Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, Sassari, 07100, Italy.
BMC microbiology
|September 24, 2025
概括
吃传统的撒丁岛发酵牛奶 (casu axedu) 会显著改变大鼠肠道微生物群的组成和功能. 这种饮食变化丰富了有益的细菌和通路,促进了肠道健康,减少了炎症.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 营养科学 营养科学
背景情况:
- 发酵乳制品是地中海地区的饮食主食,富含乳酸菌和发酵代谢物.
- 关于发酵牛奶对肠道微生物群组成和代谢活动的影响的科学理解有限.
研究的目的:
- 为了研究casu axedu的影响,一个传统的撒丁岛发酵牛奶,肠道微生物群的组成和功能在老鼠模型.
- 探索发酵牛奶消费引起的代谢活动和功能变化.
主要方法:
- 对16S rRNA基因测序进行综合分析,用于分类分析.
- 用于肠道微生物群的功能分析的metaproteomics.
- 在大鼠中进行了为期8周的食补充研究.
主要成果:
- 偶尔的阿克塞杜消费导致了Phascolarctobacterium,Prevotella,Blautia glucerasea和Lactococcus lactis的丰富性增加.
- 观察到细菌多雷和类杆菌的丰度下降.
- 甲蛋白组学揭示了增强的甘油性活性,增加的酸盐生物合成,酸盐生产和微生物合成必需氨基酸 (L-氨酸,L-氨酸).
- 减少了细菌毒性因子和宿主炎症标记物.
结论:
- 在大鼠中,饮食的随机作用显著改变了肠道微生物群的组成和功能.
- 有益的种类和代谢途径的丰富与改善的肠道健康有关.
- 消费发酵牛奶显示了减少肠道炎症的潜力.
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