在甲状腺相关的眼科病变中,视网膜退化的象限不对称性改变
Weijie Liu1,2, Wei Rao1,2, JunYe Zhu1,2
1National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Journal of translational medicine
|September 24, 2025
概括
视网膜毛细血管密度的象限不对称性在甲状腺相关眼科医症 (TAO) 中发生变化. 在TAO眼中的鼻毛细血管密度下降与视野异常相关,有助于TAO检测.
科学领域:
- 眼科医生 眼科 眼科
- 医疗成像医学成像
- 内分泌学 在内分泌学.
背景情况:
- 甲状腺相关的眼病 (TAO) 是一种影响眼睛的自身免疫性疾病.
- 在TAO中,视网膜微血管结构的变化可能发生,但其具体作用尚未完全理解.
- 辐射周囊毛细管 (RPC) 网络对于视网膜功能至关重要.
研究的目的:
- 量化TAO患者视网膜RPC密度中的象限不对称性 (QA).
- 调查RPC密度变化与TAO之间的关联.
- 探索子场RPC密度和视野平均偏差 (MD) 之间的关系.
主要方法:
- 光学连贯断层扫描血管学 (OCTA) 用于分析80个TAO眼和51个对照眼中的RPC密度.
- 象限不对称性 (QA) 被计算为四个子领域的最大和最小RPC密度之间的差异.
- 线性回归分析评估了子场RPC密度和视野MD之间的相关性.
主要成果:
- 与对照人群相比,TAO眼中的RPC密度QA显著更高 (P < 0.001).
- RPC密度的QA显示了TAO的高诊断值 (AUC = 0.816).
- 在TAO眼中观察到鼻腔RPC密度的显著下降 (P < 0.001),与视野MD相关 (P = 0.005).
结论:
- 在RPC密度QA的变化是TAO的特征.
- 降低鼻腔RPC密度是TAO的一个关键发现,与视野缺陷有关.
- RPC密度QA可以作为TAO诊断和监测的潜在生物标志物.
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