时空微环境景观和恶性上皮细胞模式转变在乳腺管道癌的进展
Xifu Cheng1,2, Wenjuan Zeng3, Bingzhe Yin4
1Data Governance Center, Nanchang People's Hospital Affiliated of Nanchang Medical College, Nanchang Medical College, 330006, Nanchang, China.
Journal of translational medicine
|September 24, 2025
概括
乳腺管道癌的进展涉及瘤微环境 (TME) 和细胞行为的变化. 向FAM111B和相关的代谢途径为增殖癌细胞提供了潜在的治疗策略.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 基因组学就是基因组学.
背景情况:
- 瘤微环境 (TME) 和癌细胞异质性使理解乳腺管道癌的预后变得复杂.
- 在疾病进展过程中,癌细胞分阶段的行为及其与TME的关系仍然不清楚.
研究的目的:
- 在乳腺管道癌的进展过程中揭示空间TME结构和细胞信息 (DCIS到IDC和转移).
- 了解TME和乳腺管道癌的预后之间的关系.
主要方法:
- 利用单细胞,空间和批量RNA测序来分析TME和瘤细胞的转录变化.
- 采用免疫组织化学,多重免疫光学,流细胞计,入侵试验和西式涂抹进行验证.
主要成果:
- 在入侵期间识别了TEX,iTreg和压力-TAM积累;在淋巴结转移中,ntregs和天真的CD8 T细胞.
- 发现的CD4 TN和细胞巨的与良好的预后相关,在进展过程中丢失.
- 发现扩散性乳腺导管癌富含转移,表达高TCA和氧化酸化代谢的FAM111B.
- 已证明的FAM111B沉默会导致细胞循环停止,并减少入侵,迁移,质亡和脱硫亡的媒介.
结论:
- 特定阶段的TME特征与乳腺管道癌中的瘤细胞行为相关.
- 在导管癌的进展过程中建立了免疫抑制的TME.
- 淋巴结转移显示了变化的微环境,增加了癌细胞的增殖和死亡.
- FAM111B抑制剂和cuproptosis/disulfidptosis的诱导剂是增殖子组的潜在治疗标.
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