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眼球表面的微环境:一个系统的审查

Sana Niazi¹, Farideh Doroodgar¹, Stephen Pflugfelder²

¹Translational Ophthalmology Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Eye and vision (London, England)

|September 24, 2025

概括

角包括炎症和眼睛表面的变化. 管理这些,包括炎症和膜功能障碍,可以改善患者对这种渐进的角膜疾病的结果.

科学领域:

眼科医生眼科眼科
角膜疾病角膜疾病
眼睛表面疾病眼睛表面疾病

背景情况:

角膜是一种渐进的角膜脱落性疾病,导致视力受损.
眼睛表面状况,如干眼,可能会影响形的发展和进展.
人们越来越认识到眼睛表面微环境在角质中的作用.

研究的目的:

综合审查形和眼皮表面疾病之间的关系.
为了检查在角膜期间眼睛表面的微环境变化.
探索这些变化的临床影响.

主要方法:

系统审查2025年1月之前发表的研究.
在主要数据库中进行的搜索:PubMed,Scopus,Cochrane,Embase,Web of Science和谷歌学者.
包括的研究根据PROSPERO注册 (ID:CRD42025643808) 进行了资格审查.

主要成果:

角与眼皮表面疾病具有相同的炎症特征,呈现高联素 (IL) -1β,IL-6,瘤缩因子 (TNF) -α和矩阵金属蛋白酶 (MMP) -9.
这些炎症标志物有助于细胞外基质降解和角膜稀薄.
眼膜的不稳定性,脂质分泌的改变和氧化压力加剧了角质的进展,表明这是一个由炎症驱动的疾病.

结论:

眼睛表面微环境与角膜之间存在着复杂的关系.
控制眼表面炎症,氧化应激和膜功能障碍至关重要.
针对眼睛表面微环境的干预措施可能会改善角患者的治疗结果.

关键词:

视角膜视角膜是一个角质上皮是角质上皮.干眼疾病是干眼的疾病.克拉托科努斯 (Keratoconus) 是一种形状的形状.眼睛表面的表面是眼睛的表面.

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