持续的虚弱缓解和未来心血管疾病风险:英国生物银行的一项纵向研究
Mengting Liu1, Qiang Zhang1, Lianke Wang1
1School of Nursing and Health, Zhengzhou University, NO.101 Kexue Road, High-Tech Development Zone of States, Zhengzhou, 450001, Henan Province, P. R. China.
Archives of public health = Archives belges de sante publique
|September 24, 2025
概括
持续的身体虚弱缓解与心血管疾病 (CVD) 的风险降低有关. 扭转脆弱性可能是预防心血管疾病的关键干预目标.
科学领域:
- 老年学是一门学科.
- 心血管医学 心血管医学
- 公共卫生 公共卫生
背景情况:
- 身体虚弱是一种可逆的情况,也是心血管疾病 (CVD) 的重要危险因素.
- 对于持续的脆弱性缓解及其对心血管疾病发展的后续影响的理解有限.
- 这项研究研究了持续的虚弱缓解与心血管疾病发病率之间的关联.
研究的目的:
- 评估持续虚弱缓解和发生心血管疾病 (CVD) 的风险之间的关系.
主要方法:
- 利用了来自英国生物库的数据,使用脆性表型评估身体脆弱性.
- 通过使用ICD-10代码 (I00-I99) 分析了三波 (实例0,1和2) 的脆弱性过渡模式,并定义了使用ICD-10代码 (I00-I99) 的事件CVD.
- 使用Cox比例危险模型,按年龄和性别分层,计算危险比率 (HR) 和95%置信区间 (95%CI).
主要成果:
- 包括2,391名参与者 (平均年龄为54.97岁);1,513人保持强壮,351人实现持续的虚弱缓解.
- 在4.6年的中位数随访期间,508名参与者患有心血管疾病.
- 持续的虚弱缓解与未来心血管疾病风险降低相关 (HR=0.72,95% CI:0.53-0.99) 与稳定的前虚弱/虚弱个体相比,特别是中年成人和女性.
结论:
- 身体虚弱的持续缓解与患心血管疾病的风险降低有关.
- 身体脆弱可能是心血管疾病风险的早期预测因素,突出其作为治疗干预的目标潜力.
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