弥合预防差距:在欧盟框架计划下,预防为重点的生物医学研究的资金分配和方法转变
Francesca Pistollato1, Fabia Furtmann2, Annalisa Gastaldello3
1Humane World for Animals, Europe, Brussels, Belgium. fpistollato@humaneworld.org.
Journal of translational medicine
|September 24, 2025
概括
生物医学研究表明,预防的重点存在着持续的差距,很少有项目涉及到初级,二级或三级预防. 转向以人为中心的方法对于公共卫生的进步至关重要.
科学领域:
- 生物医学研究与公共卫生
背景情况:
- 非传染性疾病 (NCDs) 导致了全球74%的死亡,这凸显了预防的必要性.
- 生活方式干预,生物标志物和有效的疾病管理是预防的关键.
- 预防策略对于非传染性疾病和传染性疾病都至关重要,生活方式因素发挥着重要作用.
研究的目的:
- 评估欧盟资助的生物医学研究中初级,二级和三级预防的整合和重点.
- 确定具有高度预防整合的生物医学研究领域.
- 为了比较基于动物的与以人为中心的研究方法在预防中的使用.
主要方法:
- 对第七个框架计划 (FP7) 资助的项目进行回顾性分析,包括"2020年视野"和"欧洲视野" (HE).
- 利用自然语言处理 (NLP) 来分析预防方面和研究方法.
- 检查了以预防为重点的项目的比例和不同研究领域的资金分配.
主要成果:
- 在以预防为重点的研究中存在很大的差距,在FP7,H2020和HE中,只有1.9%~4.5%的项目解决了预防问题.
- 在欧洲视野计划下,预防重点在诸如年龄相关疾病和糖尿病等领域下降.
- 虽然以动物为基础的研究是温和的 (26%),但在最近的计划下,其在特定领域的使用增加了;在高等教育下,对二级和三级预防的资金也减少了.
结论:
- 迫切需要在生物医学资金中增加以预防为重点的研究的比例.
- 转向以人为中心的方法对于提高研究结果的可翻译性至关重要.
- 为未来的欧盟政策框架推以人为本的预防研究为重点的有针对性的资金战略.
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