视网母细胞瘤的动脉内化疗:现实世界的经验
Abhishek Das1, Kothapally Saiteja, Parag K Shah
1Department of Pediatric Retina & Ocular Oncology, Aravind Eye Hospital & Postgraduate Institute of Ophthalmology, Coimbatore, Tamil Nadu.
International ophthalmology clinics
|September 25, 2025
概括
动脉内化疗 (IAC) 有效治疗视网膜母细胞瘤 (RB),达到高的全球救援率. 然而,仔细监测不良影响至关重要,特别是在资源有限的环境中.
科学领域:
- 眼科医生 眼科 眼科
- 儿科瘤学 儿科瘤学
- 医疗治疗 医疗治疗
背景情况:
- 动脉内化疗 (IAC) 是对视网膜母细胞瘤 (RB) 的标准治疗方法.
- 在各种人群中评估IAC结果对于完善治疗方案至关重要.
研究的目的:
- 评估IAC对印度队列中的视网膜母细胞瘤的疗效,安全性和挑战.
- 在RB管理中分析全球救援率,瘤回归和与IAC相关的不良事件.
主要方法:
- 在20名接受IAC治疗的视网膜母细胞瘤患者中,对21只眼睛进行了回顾性分析.
- 药物包括梅尔法兰,托波特坎和卡博普拉丁在各种组合中.
- 眼睛使用国际视网母细胞瘤分类 (ICRB) 标准进行分期.
主要成果:
- 在接受治疗的81%的眼睛中,成功地挽救了眼球,平均随访时间为20个月.
- 在57%的眼睛中发生了完整的瘤回归,在43%的眼睛中出现了部分回归.
- 副作用包括玻璃体出血,视网膜脱落,冠状动脉缺血和眼动脉狭窄.
结论:
- 动脉内化疗是对视网膜母细胞瘤的有效治疗方法,提供高的全球救援率.
- 对IAC相关的不良影响的认识和管理对于最佳的患者结果至关重要.
- 这项研究为IAC在资源有限的环境中的实际应用和局限性提供了有价值的见解.
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