产前抑郁症和SSRI暴露对儿童的影响:系统性审查
Rubina Fray Gogolu1, Alexander Tobias Ysbæk-Nielsen1, Jon Lansner1
1Department of Psychology, University of Copenhagen, Denmark.
Journal of psychopharmacology (Oxford, England)
|September 25, 2025
概括
产前抑郁症 (AD) 和产前SSRI暴露可能会影响儿童的发育,导致行为和神经学的差异. 由于研究的局限性,解开这些影响是具有挑战性的,需要进一步研究.
科学领域:
- 发展心理学 发展心理学
- 神经科学是一个神经科学.
- 围产阶段精神病学 围产阶段精神病学
背景情况:
- 产前抑郁症 (AD) 影响7%-13%的孕妇,对母亲和孩子的福祉构成风险.
- 选择性血清素再吸收抑制剂 (SSRI) 是阿尔茨海默病的常见治疗方法,但它们的独特发育效应尚不清楚.
研究的目的:
- 系统地审查AD和子宫内SSRI暴露对儿童发育的行为和神经系统后果.
- 为了区分单独的AD和AD与产前SSRI暴露的AD对发育结果的影响.
主要方法:
- 进行了对四个主要数据库 (PubMed,PsycInfo,Web of Science,Scopus) 的系统审查.
- 根据PICO框架选择了研究,将AD仅暴露的儿童与AD和在子宫内SSRI暴露 (AD + SSRI) 的儿童进行比较.
- 14篇文章符合分析的纳入标准.
主要成果:
- 与对照组相比,AD-only和AD+SSRI暴露都与皮质膜系统的改变,语言延迟以及内部化/外部化问题的增加有关.
- 特别地,AD+SSRI暴露与皮质体内系统变化和精神运动功能受损有关.
- 仅仅对AD的暴露显示出白质体积的急剧增加和婴儿兴奋度得分的降低. 两组之间在注意力或干扰抑制方面没有发现显著差异.
结论:
- 产前抑郁症和产前SSRI暴露都会影响儿童的发育,但它们的具体影响很难分离出来.
- 观察性研究的局限性和混因素凸显出需要更严格的研究来澄清这些发育影响.
- 进一步的研究对于了解AD和SSRI对儿童发育结果的不同贡献至关重要.
更多相关视频
相关概念视频
Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs
1.4K
Tricyclic Antidepressants (TCAs), including Desipramine (Norpramin), Imipramine (Tofranil), Clomipramine (Anafranil), and Amitriptyline (Elavil), inhibit serotonin and norepinephrine reuptake and also block other receptors. They are used for depression, pain conditions, and insomnia. Common adverse effects include anticholinergic effects, sedation, orthostatic hypotension, and weight gain. They have a narrow therapeutic window and so require plasma-level monitoring. Abrupt discontinuation can...
1.4K
Antidepressant Drugs: MAOIs and Other Agents
828
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
828
Antidepressant Drugs: Overview
1.4K
Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...
1.4K
Depression: Overview
794
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
794
Depressive Disorders: Etiology
444
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
444
Attention-Deficit/Hyperactivity Disorder
776
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
776


