来自Mallotus philippinensis水果的复杂基架作为潜在的iNOS抑制剂
Yen Thi Hoang Kieu1, Hiroyuki Hattori2, Masako Toda2
1The United Graduate School of Agricultural Science, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
Journal of natural products
|September 25, 2025
概括
在Mallotus philippinensis的果实中发现了6种新的复杂二维,扩大了已知的化学多样性. 鲁纳赫尔康 (Runachalcone F) 通过抑制氧化合成酶显示出潜在的抗炎性质.
科学领域:
- 自然产品化学 自然产品化学
- 药用化学 医学化学
- 植物化学 植物化学
背景情况:
- 哈尔科因是自然和合成化合物中具有重要的生物活动的重要结构动图.
- 马洛图斯菲律宾人是众所周知的多种石英的来源,包括罕见的复杂二维形状.
- 在此之前,从该物种中只发现了五种复杂的二维石.
研究的目的:
- 发现和表征来自Mallotus philippinensis的新型复杂二维石刻.
- 为了研究分离的化合物的抗炎潜力.
主要方法:
- 用NMR光谱和HR-ESIMS分离和阐明六种新化合物的结构, runachalcones A-F,使用NMR光谱和HR-ESIMS.
- 通过基于J的分析,ROESY和量子力学ECD计算来确定绝对配置.
- 在体外抗炎测定使用RAW 264.7用脂多糖 (LPS) 刺激的巨细胞.
主要成果:
- 六个新型复杂的二维石,被指定为 runachalcones A-F,被成功分离和识别.
- 新化合物的平面结构和绝对配置被严格确定.
- 鲁纳哈尔F显著抑制了LPS诱导的可诱导的氧化合成酶 (iNOS) 蛋白质表达和氧化的产生.
结论:
- 发现A-F runachalcones扩大了已知的二度 chalcones 的化学多样性.
- 马洛图斯菲律宾的果实代表了复杂的自然产品的未被探索的来源.
- 鲁纳卡尔F显示出有前途的抗炎活性,需要进一步调查.
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