福萨普雷皮坦特 (Fosaprepitant Dimeglumine) 缓解登革热病毒感染和病毒诱导的炎症反应
Xueyi Deng1, Ningze Zheng1, Shurui Liu1
1Institute of Human Virology, Department of Pathogen Biology and Biosecurity, and Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
一种抗恶心药物Fosaprepitant dimeglumine有效抑制登革热病毒 (DENV) 复制,并减少与登革热相关的严重炎症. 这一发现表明它有可能被重新用作登革热抗病毒疗法.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 登革热病毒 (DENV) 感染是一个重大的全球健康问题.
- 目前的登革热治疗主要是支持性,缺乏向的抗病毒疗法.
- 严重的登革热与免疫介导的细胞因子风暴有关.
研究的目的:
- 为了研究对DENV病毒的Fosaprepitant dimeglumine的抗病毒潜力.
- 为了评估福萨普雷皮坦特 (dimeglumine) 对DENV诱导的炎症反应的影响.
主要方法:
- 在体外研究中使用了各种细胞系 (A549,THP-1巨细胞) 和DENV复制体系统.
- 进行了剂量反应和药物添加/消除时间测试.
- 在受感染的巨细胞中量化益炎性细胞因子 (IL-6,IP-10).
主要成果:
- 佛萨普雷皮坦特 (dimeglumine) 证明了对DENV复制的剂量依赖性抑制 (IC50值为3.264.20μM).
- 该药物在病毒复制周期的后期阶段起作用,即进入后.
- 在巨细胞中显著抑制DENV诱导的IL-6和IP-10水平.
结论:
- 佛萨普雷皮坦特 (dimeglumine) 有效地抑制了DENV复制,并减弱了关键的炎症标志物.
- 这种FDA批准的药物显示出在重症登革热治疗中重新使用的希望.
- 需要进一步研究福萨普雷皮坦特 (fosaprepitant dimeglumine) 作为登革热治疗药物.
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