阿弗拉托克素B1通过调解线粒功能障碍和线粒体毛孔形成,诱导细胞中的亡和亡
Xinyu Yao1, Min Gao1, Jing Lu1,2
1College of Food Science and Engineering, Jilin University, Changchun, Jilin 130062, People's Republic of China.
Journal of agricultural and food chemistry
|September 25, 2025
概括
非洲毒素B1 (AFB1) 通过连接热和亡,导致损伤. 抑制D-N (GSDMD-N) 气皮素可以防止这种毒性,这对食品安全至关重要.
科学领域:
- 毒理学 毒理学 毒理学
- 细胞生物学 细胞生物学
- 病理学 病理学 病理学
背景情况:
- 非洲毒素B1 (AFB1) 是一种流行的真菌毒素,已知有毒性.
- 由于AFB1引起的毒性,其确切的机制尚不完全理解.
- 在毒理学中,编程细胞死亡途径之间的交叉越来越被认可.
研究的目的:
- 阐明AFB1诱导的毒性背后的分子机制.
- 调查热和亡在AFB1损伤中的作用.
- 为了确定AFB1毒性的潜在治疗点.
主要方法:
- 使用了体内和体外损伤模型.
- 分析了线粒细胞衰变,活性氧物种 (ROS) 水平和溶酶体膜通透性 (LMP).
- 研究了炎症酶激活 (NLRP3,caspase-1),烧灭 (GSDMD-N) 和灭 (细胞染色体c释放).
主要成果:
- AFB1 损害了线粒,增加了 ROS 积累,并引发了 lysosomal 损伤.
- ROS激增激活了NLRP3炎症体,导致通过GSDMD-N.通过卡斯帕-1介导的热.
- GSDMD-N形成线粒体毛孔,导致细胞染色体c释放和非正规的亡级联.
结论:
- AFB1毒性涉及新型的热和亡之间的交叉声,由GSDMD-N介导的线粒体损伤弥合.
- 抑制GSDMD-N是一种潜在的治疗策略,可以对抗AFB1毒性.
- 了解这些途径对于减轻农业和食品安全中的AFB1风险至关重要.
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