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Updated: Jan 17, 2026

The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli
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[通过构建复合大肠杆菌 (Escherichia coli) 的方法进行β-基-β-甲基黄油酸的全细胞催化合成]

Jiawei Ye1, Hong Xu1, Yaxin Liao1

  • 1Key Laboratory of Industrial Biotechnology of Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, Jiangsu, China.

Sheng wu gong cheng xue bao = Chinese journal of biotechnology
|September 25, 2025
PubMed
概括

这项研究开发了一种使用L-氨酸的β-基-β-甲基黄油酸 (HMB) 的绿色生物合成方法. 优化的双酶系统实现了8.60g/LHMB的最大产量,改善了酶活性,并提供了可持续的生产.

关键词:
4-基基酸盐是二氧化碳酶.埃舍里希亚大肠杆菌 (Escherichia coli) 是一个大肠杆菌.酶蛋白表面电荷修改酶蛋白表面电荷修改整个细胞的催化作用.在β-基-β-甲基黄油酸.

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