在慢性疼痛患者中评估口服胺的不良副作用
Brian Hom1, Diane McIntee1, Yao-Ping Zhang1
1Department of Anesthesiology, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.
Saudi journal of anaesthesia
|September 25, 2025
概括
口服胺是有效的慢性疼痛. 这项研究发现,较高的口服胺剂量 (80-240毫克) 与患者的副作用增加之间没有剂量依赖的关系.
科学领域:
- 疼痛管理 疼痛管理
- 药理学 药理学是指药理学的学科.
- 临床治疗学 临床治疗学
背景情况:
- 胺是一种有效的治疗慢性疼痛在亚麻醉剂量.
- 长期治疗慢性疼痛的口服胺使用需要评估不良影响.
- 这项研究侧重于中度至高剂量的口服胺片.
研究的目的:
- 评估口服胺剂量与不良副作用之间的关系.
- 评估长期接受中度至高剂量口服胺治疗的患者的副作用发生率.
- 为了确定与口服胺治疗中不良事件相关的因素.
主要方法:
- 成年患者处方口服胺的回顾性队列研究 (2019年11月 - 2023年10月).
- 纳入标准:每日剂量≥80mg和治疗持续时间≥90天.
- 收集的数据:人口统计,并发症,处方细节和患者报告的副作用.
主要成果:
- 包括193名患者,每日剂量从80毫克到240毫克不等.
- 副作用发生率为6.0% (80-159毫克),8.3% (160-199毫克) 和10% (200-240毫克).
- 每日最大剂量与报告的副作用之间没有显著的关联 (P=0.10);年龄与此相关 (P=0.04).
结论:
- 每天服用高达240毫克的口服胺剂量并没有表明副作用的剂量依赖性增加.
- 年龄是口服胺使用者的不良副作用的重要共同变量.
- 进一步的研究可能会探索胺副作用的与年龄相关的风险因素.
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