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相关概念视频

Solubility03:00

Solubility

20.9K
Solution, Solubility, and Solubility Equilibrium
A solution is a homogeneous mixture composed of a solvent, the major component, and a solute, the minor component. The physical state of a solution—solid, liquid, or gas—is typically the same as that of the solvent. Solute concentrations are often described with qualitative terms such as dilute (of relatively low concentration) and concentrated (of relatively high concentration).
In a solution, the solute particles (molecules,...
20.9K
Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model01:09

Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model

770
Various dissolution theories provide insight into the factors that influence the dissolution rate. Danckwerts' Model suggests that turbulence, rather than a stagnant layer, characterizes the dissolution medium at the solid-liquid interface. In this model, the agitated solvent contains macroscopic packets that move to the interface via eddy currents, facilitating the absorption and delivery of the drug to the bulk solution. The regular replenishment of solvent packets maintains the...
770
Theories of Dissolution: Diffusion Layer Model01:15

Theories of Dissolution: Diffusion Layer Model

1.6K
Dissolution, the process by which drug particles dissolve in a solvent, is explained by the diffusion layer model, a theoretical framework that simulates the absorption of oral drugs and allows us to analyze experimental data.
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...
1.6K
Recrystallization: Solid–Solution Equilibria01:10

Recrystallization: Solid–Solution Equilibria

2.5K
Recrystallization is a purification technique used to separate impurities from solid compounds. In this technique, no chemical reactions occur. Instead, it exploits physical properties only, specifically, the solubility differences between the desired compound and impurities, either at a single temperature or at different temperatures, and under other selected conditions. The solid-solution equilibrium (solubility equilibrium) of each component in the solution represents a binary phase...
2.5K
Washing, Drying, and Ignition of Precipitates00:52

Washing, Drying, and Ignition of Precipitates

5.5K
After filtration, the precipitate is washed to remove coprecipitated impurities and any remaining mother liquor. Colloidal precipitates, such as silver chloride, are washed with an electrolyte (such as dilute nitric acid) to prevent the peptization of the precipitate. In the case of slightly soluble precipitates, the wash solution contains a common ion to reduce solubility. Lead sulfate, which is slightly soluble in water, is washed with dilute sulfuric acid. Similarly, wash solutions may be...
5.5K
Factors Affecting Solubility04:01

Factors Affecting Solubility

36.7K
Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Chȃtelier’s principle. Consider the dissolution of silver iodide:
36.7K

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相关实验视频

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Methods for the Self-integration of Megamolecular Biopolymers on the Drying Air-LC Interface
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干燥模型溶剂的过程开发研究研究

Nicholas H McCarthy1, Norah S Alsaiari1,2, Thomas Brown3

  • 1School of Chemical and Process Engineering, University of Leeds, Leeds LS2 9JT, U.K.

Organic process research & development
|September 25, 2025
PubMed
概括
此摘要是机器生成的。

开发了一种新型的Schiff基溶盐,用于研究药品中有机溶剂干燥挑战. 控制的结晶产生了更大的晶体和可扩展的过程,为工业干燥应用提供了一个有前途的模型.

关键词:
结晶化 结晶化的过程.溶解解脱的过程中,干燥 干燥 干燥 干燥迷你糖是什么意思 迷你糖是什么意思酸盐溶剂的使用方法

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科学领域:

  • 化学工程是化学工程的重要组成部分.
  • 结晶科学 结晶科学
  • 制药制造业 制药制造业 制药制造业

背景情况:

  • 干燥有机溶酸盐在缩放和理解方面存在挑战,原因是溶剂去除困难和对晶体属性的控制不佳.
  • 这些问题在制药行业中至关重要,要求对活性药物成分 (API) 制定严格的质量标准.

研究的目的:

  • 为研究和优化干燥过程,开发一种具有成本效益的希夫基溶盐,是API的代表.
  • 建立一个可扩展和高收益的结晶方法,用于模型溶解物.
  • 描述工业干燥应用中的溶酸盐的特性及其解溶行为.

主要方法:

  • 从o-vanillin和para-aminobenzoic酸合成希夫基,以形成甲醇溶盐.
  • 通过播种和控制的试剂添加来优化结晶,以管理超和.
  • 使用粉末X射线衍射 (XRD) 进行晶体形态和多态的表征.
  • 开发一种定量XRD方法来评估溶剂含量.

主要成果:

  • 成功将结晶过程扩大到1L尺度,达到93%的产量和高度.
  • 晶体形态的修改,有利于增长而不是核化,导致更大,更高的比例晶体 (8到20).
  • 从溶解希夫基逐渐转化为明显的脱溶解多态的观测,可通过XRD量化.
  • 鉴定该化合物作为一个有前途的模型溶剂,由于其形态,稳定性和有利的溶解温度.

结论:

  • 开发的希夫基溶盐作为一个有效的模型系统,用于研究工业相关的干燥过程.
  • 优化的结晶策略克服了产量,度和晶体特性方面的挑战.
  • 该化合物的特性使其适合在受控条件下研究溶剂去除和溶解.