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在波兰流行病学上成功的沙门氏菌肠炎菌的分子特征

Ewelina Kamińska¹, Magdalena Zając², Magdalena Skarżyńska²

¹Department of Omic Analyses, National Veterinary Research Institute (PIWet-PIB), Puławy, Poland.

Transboundary and emerging diseases

|September 25, 2025

概括

在波兰的沙门氏菌菌.

科学领域:

食品安全食品安全
微生物学微生物学
基因组学就是基因组学.

背景情况:

自2014年以来,尽管家禽消费量下降,但人类沙门氏菌的趋势在欧盟停滞不前.
波兰是欧盟领先的家禽生产国,因此成为调查沙门氏菌流行病学的关键地区.

研究的目的:

分析波兰沙门氏菌菌菌株的遗传含量和相关性.
了解影响波兰家禽食品链和人类病例中的沙门氏菌传染病学的遗传因素.

主要方法:

275种来自家禽和人类来源的沙门氏菌菌株的全基因组测序 (2008-2019).
对抗微生物耐药性基因 (ARG),醇耐药性决定区域 (QRDR) 突变,等离子体复制品和沙门氏菌病原性岛屿 (SPI) 的分析.
核心基因组多部位序列类型化 (cgMLST) 以评估菌株相关性.

主要成果:

大多数菌株 (99.3%) 属于序列类型11 (ST11).
在5.8%的菌株中发现了抗菌素耐药性基因;在46.9%的菌株中发现了QRDR突变.
在95.6%的菌株中检测到等离子体复制体,其中IncFII(S)_1和IncFIB(S)_1是最常见的. SPI的组成基本上是统一的.

结论:

没有研究的特定遗传决定因素似乎导致了沙门氏菌传染病学的停滞.
需要对诸如改善的监测和控制措施等因素进行进一步的调查,以解释感染趋势.

关键词:

ST11 ST11 在这里.沙门氏菌沙门氏菌沙门氏菌在WGS中,使用的是WGS.抗微生物耐药性抗微生物耐药性 cgMLST 的意思毒性毒性是一种毒性.

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