使用三种不同的运动管理策略进行肺SBRT的剂量测量和治疗效率比较
Taliah Lansing1, Wendy Harris1, Mitchell Yu1
1Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Clinical and translational radiation oncology
|September 25, 2025
概括
与自由呼吸 (FB) 相比,深吸呼吸 (DIBH) 和呼吸道门 (RG) 在肺部立体体辐射疗法 (SBRT) 中减少了肺部剂量. DIBH和RG也增加了治疗时间,为改善剂量测量提供了权衡.
科学领域:
- 辐射瘤学 辐射瘤学
- 医学物理 医学物理
- 胸部瘤学 胸部瘤学
背景情况:
- 肺部立体体辐射疗法 (SBRT) 需要精确的瘤向,以最大限度地减少对周围肺组织的辐射暴露.
- 运动管理策略,如深呼吸呼吸 (DIBH),自由呼吸 (FB) 和呼吸门 (RG),用于解决呼吸引起的瘤运动.
- 将这些策略的剂量计和效率结果进行比较对于优化肺SBRT治疗计划至关重要.
研究的目的:
- 用DIBH,FB和RG技术量化比较肺SBRT的剂量测量和治疗效率.
- 提供数据,可以帮助临床医生为个别肺部SBRT患者选择最合适的运动管理策略.
主要方法:
- 对308名肺部SBRT患者进行了回顾性分析,这些患者接受了体积调制弧线疗法 (VMAT) 和6个MV平面化无波器 (FFF) 束治疗.
- 根据运动管理策略,患者被分为三个组:DIBH (n=151),FB (n=136) 和RG (n=21).
- 剂量计参数 (平均肺剂量,V5,V20) 和治疗时间 (表上,成像和验证,分娩) 被收集并在各组进行统计比较.
主要成果:
- DIBH队列表现出最低的平均肺剂量 (408.2 cGy),V5 (20.1%) 和V20 (5.7%).
- FB队列显示了最高的平均肺剂量 (569.8 cGy),V5 (27.6%) 和V20 (8.4%).
- 与FB相比,DIBH和RG的治疗时间最长,DIBH在桌上需要22.3分钟,成像/验证需要16.0分钟,分娩需要6.3分钟.
结论:
- 这项研究提供了量化证据,支持DIBH和RG在肺SBRT中相比FB的剂量学益处.
- 虽然DIBH和RG导致治疗时间增加,但它们的上肺节省可能证明了延长的持续时间.
- 这些发现使得临床医生有了数据,能够在肺SBRT中做出关于运动管理策略的明智决策.
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