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Updated: Jan 17, 2026

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies
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机器学习和门德尔随机化识别了六个细胞死亡相关基因,驱动性结肠炎的进展和治疗反应

Longfei Dai1, Weiguo Zhou1, Along Li1

  • 1Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People's Republic of China.

Journal of inflammation research
|September 25, 2025
PubMed
概括

通过机器学习和门德尔随机化确定了六个关键细胞死亡相关基因 (CDG),为性结肠炎 (UC) 严重程度和治疗反应提供了潜在的生物标志物.

关键词:
门德尔的随机化VNN1 VNN1 是一个国家.细胞死亡是细胞死亡.机器学习是机器学习.性结肠炎是一种

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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