与代谢功能障碍相关的脂肪性肝病相关的肝外并发症; 一个三级医院的经验
Masoudreza Sohrabi1, Mozhdeh Mosalli1, Parvin Hassanzadeh1
1Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran.
与代谢功能障碍相关的脂肪性肝病 (MASLD) 与肝脏以外的许多健康问题有关. 这项研究发现,MASLD严重程度与高血压,糖尿病和睡眠质量差等疾病之间存在显著的关联.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内部医学 内部医学
- 公共卫生 公共卫生
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的全球健康问题.
- MASLD越来越多地被认为与各种肝外共患病有联系.
- 了解这些并发症对于有效管理MASLD至关重要.
研究的目的:
- 调查MASLD患者肝外共患病的流行率和重要性.
- 突出需要一个全面的,多学科的方法来管理MASLD.
- 为了确定与肝硬化和纤维化严重程度相关的特定并发症.
主要方法:
- 在一个三级保健中心进行了一项横截面研究.
- 使用超声波诊断脂肪肝;其他肝脏疾病被排除在外.
- 收集了肝硬度,临床数据,肝功能测试和心理评估 (DASS-21,PSQI).
主要成果:
- 在385名参与者中,50.6%患有严重的肥胖症,29.1%患有严重的纤维化.
- 高血压,糖尿病和睡眠质量差与MASLD严重程度显著相关 (P<0.05).
- 抑郁和焦虑得分在不同纤维化和肥胖症水平之间显示出显著差异 (P<0.05).
结论:
- MASLD是一种全身性疾病,具有多种肝外表现.
- 对MASLD患者进行糖尿病,心血管疾病和精神健康问题等并发症的查是必不可少的.
- 及早发现并发性疾病并对其进行管理,可以改善患者的治疗结果,并预防疾病的进展.
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