表观遗传和结构性大脑衰老及其与重大抑郁症相关联
Eileen Y Xu1, Claire Green1, Daniel L McCartney2
1Division of Psychiatry, Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, United Kingdom.
Biological psychiatry global open science
|September 25, 2025
概括
重度抑郁症 (MDD) 与过早的生物衰老有关. 这项研究发现大脑衰老,DNA甲基化衰老和终身MDD之间有共同和明显的关联,但不是当前的MDD.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 精神病学是一个精神病学.
背景情况:
- 大型抑郁症 (MDD) 越来越多地与过早的生物衰老有关.
- 以前的研究经常独立地检查了基于大脑 (BrainAge) 和基于DNA甲基化 (DNAmAge) 的生物年龄 (BioAge) 的生物年龄.
研究的目的:
- 调查BrainAge和DNAmAge与一生和当前MDD的关联.
- 探索早期大脑和DNA甲基化衰老对MDD的共同和独特贡献.
主要方法:
- 利用了来自苏格兰世代 (GS:STRADL) 和英国生物银行 (UKB) 的截面数据.
- 通过使用预测年龄差 (PAD) 评估了BrainAge和四个DNAmAge测量 (Horvath,Hannum,GrimAge,PhenoAge).
- 控制年龄,性别,吸烟和酒精摄入量;使用后勤回归来分析关联.
主要成果:
- 在GS中,终身MDD与明显更高的脑年龄和DNAmAge (1.60-2.45年) 相关,除了Horvath年龄.
- 终身MDD显示了与GrimAge-PAD,PhenoAge-PAD和Brain-PAD (OR=1.21-1.30) 在GS和Brain-PAD (OR=1.05) 在UKB的显著关联.
- 现年PAD和脑PAD一起解释了终身MDD的最大变异 (AUC=0.69,R2=9%);对于当前的MDD没有发现任何关联.
结论:
- 早期的大脑衰老和DNA甲基化衰老都显示出与终身MDD的共同和独特关联.
- 这些发现有助于理解与抑郁相关的生物衰老过程.
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