在2型糖尿病中,血清25-基维生素D和益生菌之间的非线性因果关系:从临床和门德尔随机化分析的证据
Jing He1, Ying-Chuan Yin1, Wang Zhang2
1Department of Endocrinology, The Third People's Hospital of Hefei, Hefei Third Clinical College of Anhui Medical University, Hefei, 230022, China.
Metabolism open
|September 25, 2025
概括
维生素D不足在2型糖尿病中很常见. 这项研究在T2DM男性中发现了维生素D和益生菌之间的非线性联系,其中影响益生菌水平的值效应.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 营养科学 营养科学
背景情况:
- 全球范围内,2型糖尿病 (T2DM) 的患病率正在上升.
- 维生素D缺乏症经常与T2DM同时发生.
- 作为新陈代谢调节剂的益生菌的作用及其与T2DM中维生素D的相互作用尚未得到充分理解.
研究的目的:
- 调查T2DM男性患者的维生素D状况和益乳素水平之间的关联.
- 探索25-氧维生素D (25(OH) D和益生菌之间的潜在非线性关系和因果关系.
主要方法:
- 对221名男性T2DM患者 (年龄25-75岁) 的横截面研究.
- 测量血清25(OH) D和益生菌素的测量.
- 统计分析包括组比较,相关性,多变量回归和受限立方线.
- 孟德尔的随机化被用来评估因果关系.
主要成果:
- 在59.7%的参与者中观察到维生素D缺乏.
- 在维生素D充足的个体中发现了更高的益乳素水平.
- 确定了25OH) D和益生菌素之间的显著正相关性,在调整后仍然存在.
- 建议存在非线性关系,25(OH) D.的曲点为18.48 ng/mL.
结论:
- 在男性T2DM患者中,维生素D状态和益生菌素之间存在非线性,依赖值的关联.
- 适当的维生素D水平可以调节益乳素,并可能改善代谢结果.
- 需要进一步的研究来证实这些发现及其临床影响.
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