在低度至中度的唾液腺癌的管理实践模式:一个多机构研究
Mirabelle Sajisevi1, Kenny Nguyen2, Peter Callas2
1Division of Otolaryngology University of Vermont Medical Center Burlington USA.
Laryngoscope investigative otolaryngology
|September 25, 2025
概括
在2021年指南之前,对低级和中级唾液腺癌的管理有所不同. 口腔切除术的程度影响了面部神经的结果,辅助放射治疗的使用随着时间的推移而减少,而不会影响局部控制.
科学领域:
- 头部和部手术 头部和部手术
- 手术瘤学手术瘤学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 低级和中级的唾液腺癌是罕见的和异质的.
- 在2021年之前,这些癌症的治疗指南缺乏,导致管理实践变化.
研究的目的:
- 描述手术实践模式和低级和中级唾液腺癌患者的治疗结果.
- 在制定治疗指南之前,评估手术技术和辅助治疗对结果的影响.
主要方法:
- 分析了一份患者登记册,其中包括786名在2010年至2019年期间因低度和中度癌症而接受状腺或下部腺切除的患者.
- 评估手术前成像,活检率,外科手术 (表面与全腹切除术),面部神经结果和辅助放射治疗 (RT) 交付.
主要成果:
- 在大多数癌病例 (729名患者) 中,进行了表面或全切除术.
- 整体切除术与表面切除术相比,与增加的暂时和永久的面部虚弱有关,即使面部神经得到保护.
- 辅助性RT给了36%的患者,其使用在2015-2019年与2010-2014年相比显著下降,而这些时期之间的当地或区域控制率没有显著差异.
结论:
- 低级和中级唾液道癌的手术治疗因疾病罕见性和缺乏指导方针而表现出变化.
- 口腔切除术的程度显著影响了面部神经功能结果.
- 随着时间的推移,辅助性RT输送的下降趋势并没有影响本地或区域瘤控制,提供了数据来支持当前的指导方针并为未来的研究提供信息.
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