离子-液体-修改纳米粒子作为潜在的粘液调节器用于鼻腔药物输送
Mary E VanLandingham1, Rebekah A Heintz1, Chathuri S Kariyawasam2
1Department of Chemistry and Biochemistry, The University of Mississippi, Oxford, Mississippi 38677, United States.
基于胆碳酸的离子液体 (ILs) 可以修改通过粘膜壁垒的聚合物纳米粒子 (NP) 运输. 这项研究探讨了ILs.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 药物运输 药物运输 药物运输
背景情况:
- 粘膜壁垒对有效的药物输送构成重大挑战.
- 聚合物纳米粒子 (NP) 显示出药物输送的前景,但面临扩散限制.
- 离子液体 (ILs) 为调节生物障碍提供可调节的特性和生物相容性.
研究的目的:
- 为了研究基于胆碳酸的ILs对PLGA,PEG-PLGA和PEG-PLANP通过鼻的扩散的影响.
- 使用光谱和热量计技术分析IL-修饰的NP和粘素之间的相互作用.
- 通过实体模型评估ILs在增强鼻内药物输送方面的潜力.
主要方法:
- 多重粒子跟踪测量NP在水和粘膜环境中的扩散率.
- 紫外线光谱学和循环二元化 (CD) 光谱学用于研究NP-素相互作用和素结构变化.
- 异热定位热量计 (ITC) 用于定量约束能量的测量.
- 猪鼻腔粘膜外活体模型用于评估鼻内输送潜力.
主要成果:
- 基于胆的ILs改变了NP扩散率,特定的ILs对不同的NP类型有不同的影响 (例如,减缓PEG-PLGA,增加PEG-PLA扩散).
- ILs被证明可以稳定聚合物NP和粘素聚合物之间的相互作用.
- 光谱和热量计数据证实了NP和粘液之间的复杂形成和结合能.
- 活体研究表明,特的运输材料与改善鼻腔药物输送之间存在联系.
结论:
- 基于胆碳酸的ILs可以调节聚合物NP在粘膜环境中的运输行为.
- 这些IL显示出控制NP-mucin相互作用的潜力,为增强鼻内药物递送提供了一种战略.
- 这些发现突显了ILs在克服粘膜壁垒的实用性,以改善治疗应用.
更多相关视频
07:33Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo
Published on: September 28, 2022
10:16Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
Published on: February 8, 2017
相关概念视频
Drugs Used in Upper Respiratory Disorders: Overview
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
Drug Delivery: Miscellaneous Routes
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
Bioavailability Enhancement: Drug Permeability Enhancement
Antiasthma Drugs: Leukotriene Modifiers
Leukotriene modifiers work through two distinct mechanisms:
