上腺,社会认知,以及自闭症谱特征的发展和演变
1Department of Biological Sciences, Simon Fraser University, Burnaby, BC, Canada.
Frontiers in psychiatry
|September 25, 2025
概括
自闭症谱系障碍 (ASD) 可能与上腺的变化有关,这个过程涉及脱氨 (DHEA) 和其硫酸盐 (DHEAS). 较高的DHEA水平与自闭症诊断和社会焦虑有关,特别是在中年女孩身上.
科学领域:
- 神经发育障碍 神经发育障碍
- 内分泌学 在内分泌学.
- 遗传学 是一个遗传学.
背景情况:
- 自闭症谱系障碍 (ASD) 是一种复杂的神经发育状况,其原因和表达方式各不相同.
- 自闭症的特征可以在整个童年时期出现或发生变化,受认知发展和社会挑战的影响.
- 最近的一项研究表明,自闭症有两种发育轨迹,一种是在中儿童期晚些时候发生的,围绕上腺.
研究的目的:
- 为了调查这种假设,上腺的变化,特别是脱水氨固醇 (DHEA) 和脱水氨硫酸 (DHEAS) 水平,与ASD发病或在中儿童时期的表达有关.
- 评估DHEA/DHEAS水平与自闭症谱特征或相关大脑发育方面的联系.
主要方法:
- 进行了一系列的系统审查.
- 这些评论综合了关于DHEA或DHEAS水平与ASD,自闭症谱特征或与自闭症相关的大脑发育之间的关联的证据.
主要成果:
- 较高的DHEA水平与增加的内化和外化行为有关,包括社会焦虑,对女孩有显著的影响.
- 有证据表明,较高的DHEA水平与自闭症诊断之间存在积极的关联,这与最近的元分析一致.
- 这些发现支持了将上腺和DHEA水平的变化与在中儿童期被诊断出的自闭症亚型联系在一起的假设.
结论:
- 在中年童年期间,上腺和相关的脱水氨 (DHEA) 水平的变化可能与一种特定的自闭症谱系障碍亚型有关.
- 这些发现表明,晚发症或晚诊断的自闭症有潜在的内分泌学基础,特别是在这个发育时期的社会适应方面.
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