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针对衰老细胞进行骨再生的生物材料:最先进的技术和未来的前景

Haitong Wu¹, Qing Zhang¹, Jinhao Zhu¹

¹Department of Basic Oral Medicine, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, 510182, China.

Bioactive materials

|September 25, 2025

概括

先进的生物材料可以通过向衰老细胞来对抗与年龄相关的骨缺陷. 策略包括消除这些细胞或使骨微环境再生,以改善组织再生.

科学领域:

生物材料科学生物材料科学
再生医学是一种再生医学.
老年学是一门学科.

背景情况:

骨缺陷治疗面临挑战,特别是在老年人群中,因为老化细胞的增加.
衰老细胞及其相关分泌表型 (SASP) 通过影响组织微环境,损害骨再生.

研究的目的:

审查基于材料的策略,以对抗老化骨组织老化的衰老.
探索如何先进的生物材料可以被设计为老年人骨再生.

主要方法:

对生物材料和老化剂的当前文献的综述.
对衰老细胞消除,功能复原和微环境重塑策略的分析.
对基于生物材料的疗法临床翻译挑战的评估.

主要成果:

生物材料可以提供老化剂或调节免疫清除以消除衰老细胞.
材料可以通过减轻炎症和代谢功能障碍来恢复细胞平衡.
整体策略涉及通过生物化学和物理线索重塑骨微环境.

结论:

基于生物材料的策略为再生老化骨组织提供了有希望的途径.
克服特异性,临床前模型和监管途径方面的挑战对于临床翻译至关重要.
为设计用于骨再生的下一代生物材料提供了一个概念框架.

关键词:

生物材料是一种生物材料.骨再生骨的再生提供纳米药物输送.与衰老相关的分泌表现型衰老细胞是衰老的细胞.

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