心力衰竭中血小板体积指数的预后值:系统性审查和元分析
Amir Parsa Abhari1, Farzad Adelparvar1, Parastesh Rezvanian1
1Heart Failure Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences Isfahan, Iran.
American journal of blood research
|September 25, 2025
概括
平均血小板体积 (MPV) 显示了心力衰竭 (HF) 患者的显著预后价值,预测死亡率和发病率. 血小板分布宽度 (PDW) 在本系统性审查中没有表现出类似的预测能力.
科学领域:
- 心脏病学 心脏病学
- 血液学 血液学 血液学
- 生物标志物研究 生物标志物研究
背景情况:
- 心力衰竭 (HF) 是一个重大的全球健康挑战,需要有效的预后生物标志物来实现最佳的患者管理.
- 确定可靠的HF风险分层指标对于临床决策至关重要.
研究的目的:
- 在被诊断为心力衰竭的患者中,系统地审查和综合平均血小板体积 (MPV) 和血小板分布宽度 (PDW) 的预后值.
- 评估MPV和PDW与HF人群中不良结果 (包括死亡率和发病率) 的关联.
主要方法:
- 在主要数据库 (Medline,Scopus,Web of Science,Embase) 进行了全面的文献搜索.
- 符合条件的研究经历了严格的选,数据提取和独立审稿人的质量评估.
- 使用随机效应模型进行了元分析,使用标准统计方法评估异质性和出版偏差.
主要成果:
- 分析包括21项研究,包括12,471个记录.
- 平均血小板体积 (MPV) 显示出对HF死亡率和发病率的显著预测值 (合并OR: 1.71,95%CI: 1.5-1.91).
- MPV与NT-proBNP水平呈正相关性,并显示预后的AUC为0.75;PDW没有产生显著的预后结果.
结论:
- 平均血小板体积 (MPV) 作为心力衰竭的有价值的预后标记,与增加的死亡率和发病率相关.
- 在HF中血小板分布宽度 (PDW) 的预后意义需要进一步调查.
- 临床应用MPV可能会提高HF患者的风险分层,尽管需要更大,多样化的研究来证实研究结果并建立参考范围.
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