TNF-α诱导VE-cadherin依赖的间隙/JAIL循环通过中性粒细胞转移所必需的中间状态

Jan Philip Kipcke1,2,3, Maria Odenthal-Schnittler1,2, Mohammed Aldirawi3

  • 1Max-Planck-Institute for Molecular Biomedicine, Münster, Germany.

Frontiers in immunology
|September 25, 2025
PubMed
概括

这项研究揭示了炎症形态表型 (IMP) 对于中性粒细胞的跨内皮移动 (TEM) 是至关重要的. 它涉及由MLC酸化调节的动态缺口形成和恢复周期,提供新的治疗点.

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