增加的循环瘤细胞反映了多发性骨髓瘤的高增殖率和基因组复杂性
Juan-Jose Garces1, Benjamin Diamond2, Tereza Sevcikova3,4,5
1Myeloma Service, Department of Medicine Memorial Sloan Kettering Cancer Center New York New York USA.
HemaSphere
|September 25, 2025
概括
新诊断的多发性骨髓瘤 (NDMM) 的高循环瘤细胞 (CTC) 计数表明具有侵略性的生物学和复杂的基因组特征. 与扩散特征相比,CTC提供了更高的预后价值,有助于临床决策.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 基因组学就是基因组学.
背景情况:
- 循环瘤细胞 (CTC) 是多发性骨髓瘤 (MM) 的预后因素.
- 新诊断的MM (NDMM) 中高CTC计数的生物学基础和预后意义需要进一步阐明.
研究的目的:
- 描述与NDMM中CTC负担相关的基因组和转录组特征.
- 评估CTC,基因组和转录组数据在NDMM中的综合预后价值.
主要方法:
- 来自CoMMpass数据集的540名NDMM患者的分析与基线CTC,转录组和基因组数据.
- 在135名NDMM患者的外部队列上进行验证,使用下一代流动细胞计量来进行CTC计数.
主要成果:
- 较高的CTC水平与高风险的临床特征和复杂的基因组改变 (染色体变,APOBEC突变) 相相关.
- 升高的CTC与丰富的细胞循环/增殖 (PR) 基因和减少的免疫反应信号有关.
- CTCs表现出对PR签名的预后优越性,作为替代标记.
结论:
- 在NDMM中CTC水平升高反映了侵略性生物学,并具有显著的预后价值.
- 将CTC数据集成到现有的分类器中可以增强NDMM患者的风险分层和临床决策.
更多相关视频
05:17Micromanipulation of Circulating Tumor Cells for Downstream Molecular Analysis and Metastatic Potential Assessment
Published on: May 14, 2019
9.1K
14:14Adaptation of Semiautomated Circulating Tumor Cell CTC Assays for Clinical and Preclinical Research Applications
Published on: February 28, 2014
16.3K
相关概念视频
02:30Metastasis
6.4K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
6.4K
02:07Tumor Progression
7.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.2K
02:40Cancer Stem Cells and Tumor Maintenance
5.9K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
5.9K