产前持续暴露于有机酸和早期儿童大脑发育:一个纵向分析
Liyi Zhang1,2, Pengpeng Wang3, Yashuo Xie1,2
1Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, Shanghai 200032, China.
Environment & health (Washington, D.C.)
|September 25, 2025
概括
产前暴露于有机酸 (OPEs),特别是2-乙烯二酸 (EHDPP),与儿童的不良神经发育有关. 这项研究强调了心理健康和发展里程碑的性别特异性脆弱性.
科学领域:
- 环境健康 环境健康
- 神经发育毒理学 神经发育毒理学
- 儿科健康 儿科健康
背景情况:
- 关于产前有机酸 (OPE) 暴露和儿童神经发育,存在不一致的发现.
- 需要进行长度研究,评估多个时间点的暴露.
研究的目的:
- 调查产前OPE暴露与儿童神经发育之间的关联.
- 确定与发展结果相关的特定OPE和暴露模式.
- 探索性别特异性的脆弱性差异.
主要方法:
- 在508对母婴对的长度研究中.
- 在怀孕期间测量了母亲血清中的七个OPE.
- 在2岁和5岁时使用验证的工具评估儿童的心理健康和发展里程碑.
- 采用基于组的轨迹建模,通用估计方程和基于量子的g计算.
主要成果:
- 经常检测到四种OPE,包括2-乙烯二酸 (EHDPP).
- 增加产前EHDPP暴露与儿童更高的同龄问题得分有关.
- 暴露于EHDPP与沟通,总动力和个人-社会领域的得分较低相关.
- 男孩在心理健康方面表现出更大的敏感性,而女孩在发展里程碑方面更容易受到伤害.
结论:
- 产前OPE暴露,特别是EHDPP,与幼儿时代的不良神经发育结果有关.
- 研究结果表明,OPE对儿童心理健康和发育的性别特异性影响.
- 进一步的研究是有必要的,以了解机制,并告知预防策略.
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