外源金属通过单细胞分辨率的免疫细胞间接影响人类精液质量
Nian Liu1, Guangming Li2, Guohuan Zhang3
1School of Environment, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.
Environment & health (Washington, D.C.)
|September 25, 2025
概括
环境金属暴露通过改变精液中的免疫细胞对男性生育能力产生负面影响. 这些免疫细胞的变化反过来影响了精子质量,突出了金属,免疫力和生殖健康之间的关键联系.
科学领域:
- 环境健康 环境健康
- 生殖免疫学 生殖免疫学
- 毒理学 毒理学 毒理学
背景情况:
- 免疫调节在男性生殖健康和生育能力中起着至关重要的作用.
- 金属和金属化物以其免疫调节作用而闻名,但它们通过免疫通路对精液质量的影响尚不清楚.
研究的目的:
- 研究免疫细胞内的外源金属,免疫细胞比例和健康男性的精液质量之间的关联.
- 通过免疫细胞调节,阐明金属暴露对男性生殖健康的间接影响.
主要方法:
- 利用质量细胞计 (CyTOF) 来分析精液中免疫细胞的单细胞分辨率.
- 从84名健康男性的266个精液样本中测量了已识别的免疫细胞内的外源金属度.
- 进行调解分析,通过免疫细胞量化金属对精子参数的间接影响.
主要成果:
- 免疫细胞中检测到的大多数金属与免疫细胞比例相反相关 (p < 0.05),表明了不良影响.
- 在免疫细胞比例和关键精液质量参数 (精子度,运动性) 之间观察到非线性,N形的关联.
- 调解分析显示,免疫细胞调解了外源金属对精子质量间接影响的15.11%至54.29%.
结论:
- 外源性金属暴露会对精液中的免疫细胞产生不利影响.
- 免疫细胞的变化间接影响男性精液质量,将环境金属暴露与生殖健康联系起来.
- 研究结果提供了关于环境因素,免疫细胞和男性生育能力之间的复杂相互作用的见解.
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