生物紧张性和细胞外矩阵干扰在持续的手术后疼痛的发病:一个假设
Shiloh Plaut1,2
1Department of General and Internal Medicine, Shaare Zedek Medical Center, Jerusalem, Israel.
Frontiers in physiology
|September 25, 2025
概括
持续的手术后疼痛 (PPOP) 和纤维肌痛可能源于结缔组织功能障碍. 这一框架将细胞外矩阵恒常与机械生物神经神经疼痛机制联系起来,提供了新的研究途径.
科学领域:
- 生物医学工程 生物医学工程
- 疼痛医学 医学 疼痛医学
- 连接组织研究 连接组织研究
背景情况:
- 持续的手术后疼痛 (PPOP) 影响了30-70%的手术患者,尽管进行了广泛的研究,但病理生理学尚不清楚.
- 当前的神经生物学理论提供了有限的治疗疗效,导致生活质量下降.
- 纤维肌痛,历史上被视为连接组织疾病,缺乏明确的机械解释.
研究的目的:
- 基于连接组织和生物力学,提出PPOP病变的理论框架.
- 提出一种机械生物神经系统机制,将细胞外矩阵恒温与疼痛综合征联系起来.
- 将纤维肌痛和PPOP重新定义为相互连接的神经生物学和生物力学系统的疾病.
主要方法:
- 基于连续生物力学和细胞外矩阵恒温的理论建模.
- 整合了最近关于功能性心理疼痛中的机械生物神经系统机制的发现.
- 分析带作为一个动态的,相互连接的连接组织网络的作用.
主要成果:
- 一个新的PPOP和纤维肌痛病原学的框架,植根于连接组织机制.
- 确定肌纤维细胞过度活跃和机械应激在筋骨系统作为关键因素.
- 假设通过手术破坏生物力学稳定,从而引发慢性疼痛和神经生理变化.
结论:
- PPOP和纤维肌痛可以理解为细胞外基质和结缔组织的疾病.
- 拟议的模型强调了慢性疼痛中神经生物学和生物力学之间的相互作用.
- 这一框架为结合组织在疼痛发病过程中的作用开辟了新的研究方向.
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