基和多基物质对糖尿病病的影响
Siyuan Song1, Liji Huang1, Xiqiao Zhou1
1Department of Endocrinology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Frontiers in endocrinology
|September 25, 2025
概括
和多基基物质 (PFAS) 通过影响胰岛素抵抗等关键途径,促进糖尿病病 (DKD). 这项研究确定了特定的有毒标和机制,将PFAS暴露与DKD进展联系起来.
科学领域:
- 环境毒理学环境毒理学
- 腎臟病學 (nephrology) 是一種醫學.
- 分子生物学分子生物学
背景情况:
- 糖尿病病 (DKD) 是糖尿病的一个主要并发症.
- 和多基基物质 (PFAS) 是具有潜在不利健康影响的环境污染物.
- 暴露于PFAS和DKD病原体之间的机制联系仍然不清楚.
研究的目的:
- 阐明PFAS在DKD病变和进展中的机制性作用.
- 确定特定的PFAS相关的有毒点和涉及DKD的途径.
- 为了解PFAS诱导的DKD提供一个理论框架.
主要方法:
- 使用数据库 (PubChem,ProTox 3.0,ChEMBL) 对PFAS毒性概况的系统评估.
- 预测PFAS和DKD相关基因标,然后进行交叉分析.
- 构建蛋白质-蛋白质相互作用网络和功能丰富分析 (KEGG,GSEA).
- 通过免疫组织化学,基因表达分析和分子对接模拟进行验证.
主要成果:
- 确定了424个PFAS相关的目标和9999个DKD相关的目标.
- 在DKD中,PFAS毒性涉及胰岛素抵抗,PPAR信号传递和AMPK信号传递等途径.
- 确定了关键枢纽目标 (例如,MMP9,BCL2,ACE) 和它们在免疫媒介损伤中的潜在作用.
- 分子对接证实了PFAS和枢纽蛋白之间强烈的结合亲和关系.
结论:
- 这项研究建立了一个理论框架,以了解PFAS在DKD病变发生过程中的作用.
- 已识别的有毒目标和途径提供了关于由于PFAS暴露而导致的DKD进展的见解.
- 这些发现支持PFAS通过特定的分子相互作用在DKD中的机制性参与.
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