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语言和记忆测试:一个简短的多领域数字认知测量多发性硬化症

Victoria M Leavitt¹, Leila Simani¹, Marcus Koch²

¹Cognitive Neuroscience Division, Department of Neurology, NewYork-Presbyterian; Columbia University Irving Medical Center, New York, NY, USA.

Multiple sclerosis (Houndmills, Basingstoke, England)

|September 25, 2025

概括

新的语言和记忆测试 (LMT) 准确地测量了多发性硬化症 (MS) 的认知功能. 这种数字工具对远程监测MS患者的认知衰退有很大的希望.

科学领域:

神经科学是一个神经科学.
认知科学认知科学
数字健康数字健康

背景情况:

准确的认知评估对于管理多发性硬化症至关重要.
现有的措施可能无法完全捕捉受MS影响的认知领域,例如快速命名,视觉空间记忆和精细运动技巧.
语言和记忆测试 (LMT) 是为了满足这些需求而开发的,专门研究词汇访问作为MS相关认知衰退的驱动因素.

研究的目的:

开发和验证语言和记忆测试 (LMT),一种用于多发性硬化症 (MS) 的新的数字认知评估工具.
评估LMT测量易受MS影响的认知领域的能力,包括快速命名,视觉空间记忆和精细运动技巧.
测试这个假设,词汇访问是MS认知障碍的主要因素.

主要方法:

一项概念验证研究涉及265名患有MS的成年人和115名健康对照 (HC) 在三个国家.
参与者完成了LMT,其中一个子集还进行了多发性硬化症简要国际认知评估 (BICAMS) 和主观认知测量.
在初步分析中,评估了内部一致性,测试重复测试可靠性,区分性,构造性和融合性有效性,以及耐受性.

主要成果:

与HC相比,MS组在所有LMT子测试中表现明显差,即使对运动功能,年龄,性别和教育进行控制 (p < .05).
LMT表现出广泛可接受的重复测试可靠性和内部一致性,参与者报告的耐受性高.
结果支持了词汇访问假设,LMT子测试的表现与MS残疾和疾病持续时间相关.

结论:

语言和记忆测试 (LMT) 是一个有前途的数字认知工具,用于MS患者.
LMT表现出良好的初始区分和构造有效性,使多个认知领域的远程评估成为可能.
该工具有助于在受MS影响的不同人群中测量认知功能,支持对认知衰退机制的假设测试.

关键词:

认知能力认知能力认知能力数字工具是数字工具.语言语言语言语言语言语言.记忆记忆记忆记忆记忆多领域多领域.结果测量结果的测量.

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