相关实验视频

Updated: Jan 17, 2026

Non-Aqueous Isolation and Enrichment of Glandular Capitate Stalked and Sessile Trichomes from Cannabis sativa

Non-Aqueous Isolation and Enrichment of Glandular Capitate Stalked and Sessile Trichomes from Cannabis sativa

Published on: May 12, 2023

从人工培养的果实体中获得的诺拉诺斯坦三烯酸基底菌体 Ganoderma casuarinicola

Panida Chinthanom¹, Siriporn Saepua¹, Seangaroon Yoiprommarat¹

¹National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Klong Luang, Pathumthani 12120, Thailand.

Journal of Asian natural products research

|September 25, 2025

概括

从Ganoderma casuarinicola中鉴定出了两种新的化合物,即Ganocasuarinones B和C. 加诺卡苏阿里C显示选择性癌细胞细胞毒性,为乳腺癌研究提供了潜力.

科学领域:

自然产品化学化学
药用化学医学化学
菌类学菌类学是指菌类学.

背景情况:

Ganoderma casuarinicola是一种生物活性天然产品的来源.
三聚类是具有多种生物活性的一类化合物.
研究真菌代谢物可以导致发现新的治疗剂.

研究的目的:

为了隔离和描述来自Ganoderma casuarinicola的新型化合物.
评估针对癌症细胞系的分离化合物的细胞毒性活性.

主要方法:

使用色谱技术分离化合物.
通过核磁共振 (NMR) 谱学和质谱学阐明结构.
使用修改后的莫舍尔方法确定绝对配置.
使用人类乳腺癌细胞系MCF-7进行细胞毒性测定.

主要成果:

两种新的诺拉诺斯坦三类化合物 - - 甘诺卡苏阿林B (1) 和C (2) - - 被分离并进行了结构特征.
确定了 ganocasuarinone B (1) 的绝对配置.
甘诺卡苏阿里C (2) 对人类乳腺癌细胞的MCF-7具有选择性细胞毒性,IC50值为47μM.

结论:

甘菌 (Ganoderma casuarinicola) 产生独特的诺拉诺斯坦三烯酸.
甘素C具有选择性细胞毒性,与乳腺癌治疗相关.
对诺卡苏阿里C的进一步调查可能会产生新的抗癌药物线索.

关键词:

甘菌香草香草香草香草香草人工种植的人工种植细胞毒性活动的细胞毒性.诺兰诺斯坦尼诺兰诺斯坦尼这种植物属于多种类型的Polyporaceae.

更多相关视频

Isolation and Purification of Fungal β-Glucan as an Immunotherapy Strategy for Glioblastoma

Isolation and Purification of Fungal β-Glucan as an Immunotherapy Strategy for Glioblastoma

Published on: June 2, 2023

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

相关概念视频

Fungal Phylum Basidiomycota

Fungal Phylum Basidiomycota

Basidiomycota is a diverse phylum of fungi that includes ecologically significant decomposers such as white rot fungi, symbionts like mycorrhizal fungi, plant pathogens such as rusts and smuts, and edible species like Agaricus bisporus (the common button mushroom). These fungi play crucial roles in nutrient cycling, symbiotic relationships, and even human health. Their defining feature is the basidium, a microscopic club-shaped structure responsible for producing basidiospores.Fruiting Bodies...