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解读Biyan Qingdu颗粒的药动力学基础:综合关键药动力学成分识别,多组织分布和代谢分析
Na Zhang1, Xiang Fan2, Fengyi Lv3
1School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China.
Journal of mass spectrometry : JMS
|September 25, 2025
概括
研究了传统中医药Biyan Qingdu颗粒 (BYQD) 的活性成分和作用. 这项研究确定了各种组织中的关键化合物及其代谢,澄清了BYQD用于鼻癌放射治疗的药理学基础.
科学领域:
- 药理学和中国传统医学
- 分析化学 分析化学
- 网络药理学网络药理学
背景情况:
- 毕安青都颗粒 (BYQD) 是一种传统中医 (TCM) 配方,用于在鼻癌 (NPC) 放射治疗期间控制症状.
- 缺乏对BYQD的药学动力学物质基础的全面了解,包括其活性成分,分布和代谢.
研究的目的:
- 研究BYQD的药理动力学成分,多组织分布和生物转化过程.
- 为了确定关键的生物活性成分,并在体内建立BYQD的代谢地图.
主要方法:
- 超高性能液体染色学-高分辨率质谱学 (UHPLC-HRMS) 和UHPLC-MS/HRMS的整合.
- 网络药理和分子对接的应用用于组件优先级.
- 在六个主要组织中分析组织分布和代谢物概况.
主要成果:
- 确定了血中的20种药理动力学成分,并描述了它们在心脏,肝脏,脏,肺,脏和鼻中的分布.
- 通过使用网络药理和分子对接,优先考虑了四个关键的生物活性成分:奎尔塞丁,雅西奥西丁,α-阿洛克利普托平和马格诺弗洛林.
- 建立了BYQD的第一个多组织代谢图谱,识别了40种具有组织特异特征的I/II期代谢物.
结论:
- 这项研究系统地描述了BYQD组件的体内过程.
- 这些发现揭示了BYQD的药学动力学物质基础,为其在鼻癌治疗中的临床应用提供了关键的见解.
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