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年轻人的抗高血压治疗和心血管风险:基于人口的队列研究

Federico Rea^1,2, Gabriella Morabito^1,2, Giovanni Corrao^1,2

¹National Centre for Healthcare Research & Pharmacoepidemiology, at the University of Milano-Bicocca, Via Bicocca degli Arcimboldi, 8, Edificio U7, Milano 20126, Italy.

European heart journal

|September 25, 2025

概括

坚持服用抗高血压药物显著降低了年轻人的心血管风险,反映了中年人的好处. 这项研究强调了持续使用药物的重要性,以防止各年龄组的不良事件.

科学领域:

心脏病学心脏病学
药理学药理学是指药理学的学科.
公共卫生公共卫生

背景情况:

抗高血压药物的有效性已在老年人群中得到证实,但在年轻人群中还没有充分研究.
18-39岁个体的高血压管理需要进一步调查治疗结果.
之前的研究还没有广泛评估坚持在年轻人群中对高血压相关风险的影响.

研究的目的:

评估抗高血压药物在年轻成年人 (18-39岁) 中的保护作用.
根据年轻成年人的坚持水平,比较非致命和致命心血管结局的风险.
分析中年患者 (40-55岁) 的坚持模式,以获得比较的见解.

主要方法:

从伦巴第地区数据库 (2009-2017) 中确定了一组286,751名居民 (18-55岁) 新开处方的抗高血压药物.
药物治疗的坚持是用处方药所覆盖的随访时间的比例来量化 (≥80% vs <80%).
考克斯和因果特异性危险回归模型分析了心血管事件和死亡率的住院病例,计算了危险比率 (HR) 和95%信心区间 (CI).

主要成果:

对抗高血压药物的坚持与心血管住院危险比率 (HR) 的降低有关:在18-39岁的人群中,0.78 (95% CI 0.65-0.94);在40-55岁的人群中,0.80 (95% CI 0.76-0.84).
在老年人群中,坚持与心血管和全因死亡率 (分别为-18%和-30%) 有显著的负面关联.
在随访期间,在较年轻的年龄组中没有观察到坚持对心血管或全因死亡率的显著影响.

结论:

在现实世界中,坚持抗高血压药物治疗有效地降低了年轻人的心血管风险,与中年患者相比.
始终坚持药物治疗对于缓解广泛年龄范围内的心血管事件至关重要.
这些发现支持促进年轻人遵守抗高血压治疗的重要性,以预防长期心血管并发症.

关键词:

坚持的坚持坚持的坚持临床结果临床结果医疗保健利用数据库的数据库在高血压的高血压.基于人口的队列研究.

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